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H2AC21 H2A clustered histone 21 [ Homo sapiens (human) ]

Gene ID: 317772, updated on 5-Sep-2021

Summary

Official Symbol
H2AC21provided by HGNC
Official Full Name
H2A clustered histone 21provided by HGNC
Primary source
HGNC:HGNC:20508
See related
Ensembl:ENSG00000184270 MIM:615014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2AB; HIST2H2AB
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2AC21 in Genome Data Viewer
Location:
1q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (149887469..149887965, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149859019..149859515, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 21 Neighboring gene H2A clustered histone 20 Neighboring gene bolA family member 1 Neighboring gene synaptic vesicle glycoprotein 2A

Genomic regions, transcripts, and products

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
histone H2A type 2-B
Names
histone 2, H2ab
histone cluster 2 H2A family member b
histone cluster 2, H2ab

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175065.3NP_778235.1  histone H2A type 2-B

    See identical proteins and their annotated locations for NP_778235.1

    Status: REVIEWED

    Source sequence(s)
    AC239868
    Consensus CDS
    CCDS938.1
    UniProtKB/Swiss-Prot
    Q8IUE6
    Related
    ENSP00000332790.4, ENST00000331128.6
    Conserved Domains (1) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    149887469..149887965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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