esr2b estrogen receptor 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: esr2bprovided by ZNC
Official Full Name: estrogen receptor 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030116-1
See related: Ensembl:ENSDARG00000034181 AllianceGenome:ZFIN:ZDB-GENE-030116-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ER[b]1; abrrl6; zfER[b]1; zfER-beta1
Summary: Enables estradiol binding activity; nuclear estrogen receptor activity; and steroid hormone binding activity. Involved in sex determination. Acts upstream of or within embryonic cranial skeleton morphogenesis; response to estrogen; and swimming behavior. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including forebrain; head; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	13	NC_133188.1 (40489636..40539608)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (37040789..37073681)

Chromosome 13 - NC_133188.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developmental Delay and Male-Biased Sex Ratio in esr2b Knockout Zebrafish.
Title: Developmental Delay and Male-Biased Sex Ratio in esr2b Knockout Zebrafish.
Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development.
Title: Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development.
ER-alpha is the central factor, acting interactively with ERbeta1, ERbeta2 and GPER, and GPER regulates vitellogenesis directly and interactively with nuclear estrogen receptors.
Title: Interaction of nuclear ERs and GPER in vitellogenesis in zebrafish.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
Title: Functional Analysis of Nuclear Estrogen Receptors in Zebrafish Reproduction by Genome Editing Approach.
although esr2b mutant fish showed unaltered antibacterial responses, they were unable to mount an effective antiviral response upon viral challenge.
Title: Estrogen receptor 2b deficiency impairs the antiviral response of zebrafish.
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.
Title: Localization and divergent profiles of estrogen receptors and aromatase in the vocal and auditory networks of a fish with alternative mating tactics.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
Title: Morpholino-mediated knockdown of ERα, ERβa, and ERβb mRNAs in zebrafish (Danio rerio) embryos reveals differential regulation of estrogen-inducible genes.
Report stable reporter gene assays based on stable expression of subtypes of zebrafish ER (zfERalpha, zfERbeta1, and zfERbeta2) coupled to estrogen response element-driven luciferase in a zebrafish liver cell line.
Title: Selective activation of zebrafish estrogen receptor subtypes by chemicals by using stable reporter gene assay developed in a zebrafish liver cell line.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
Title: Levels of 17beta-estradiol receptors expressed in embryonic and adult zebrafish following in vivo treatment of natural or synthetic ligands.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta after a 21-day exposure to endocrine-disrupting chemicals.
Title: Temperature and photoperiod affect the endocrine disruption effects of ethinylestradiol, nonylphenol and their binary mixture in zebrafish (Danio rerio).

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables estradiol binding	IDA Inferred from Direct Assay more info	PubMed
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear estrogen receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables steroid hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: estrogen receptor 2b

Names: ERbeta-A; NR3A2-A; estrogen receptor beta b; estrogen receptor beta1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174862.3 → NP_777287.2 estrogen receptor 2b

See identical proteins and their annotated locations for NP_777287.2

Status: PROVISIONAL

Source sequence(s)

BC086848

UniProtKB/TrEMBL

Q5PR29

Related

ENSDARP00000063411.3, ENSDART00000063412.5

Conserved Domains (3) summary

cd06949
Location:296 → 519

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:160 → 241

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam12497
Location:31 → 132

ERbeta_N; Estrogen receptor beta

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133188.1 Reference GRCz12tu Primary Assembly

Range

40489636..40539608

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_073919307.1 → XP_073775408.1 estrogen receptor 2b isoform X1

UniProtKB/TrEMBL

A0A8M2B359, B8JJL4
XM_073919310.1 → XP_073775411.1 estrogen receptor 2b isoform X2

UniProtKB/TrEMBL

A0A8M2B3C1, B8JJL3
XM_073919306.1 → XP_073775407.1 estrogen receptor 2b isoform X1

UniProtKB/TrEMBL

A0A8M2B359, B8JJL4
XM_073919308.1 → XP_073775409.1 estrogen receptor 2b isoform X2

UniProtKB/TrEMBL

A0A8M2B3C1, B8JJL3
XM_005156972.6 → XP_005157029.1 estrogen receptor 2b isoform X1

See identical proteins and their annotated locations for XP_005157029.1

UniProtKB/TrEMBL

A0A8M2B359, B8JJL4

Related

ENSDARP00000041299.5

Conserved Domains (3) summary

cd06949
Location:304 → 527

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:160 → 249

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam12497
Location:31 → 132

ERbeta_N; Estrogen receptor beta
XM_073919309.1 → XP_073775410.1 estrogen receptor 2b isoform X2

UniProtKB/TrEMBL

A0A8M2B3C1, B8JJL3