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Tph2 tryptophan hydroxylase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317675, updated on 6-Feb-2017
Official Symbol
Tph2provided by RGD
Official Full Name
tryptophan hydroxylase 2provided by RGD
Primary source
RGD:631332
See related
Ensembl:ENSRNOG00000003880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Ntph
Summary
isoform of tryptophan hydroxylase; may play a role in seratonin biosynthesis [RGD, Feb 2006]
Orthologs
Location:
7q22
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (58042279..58149220, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (58053268..58157949, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 19-like Neighboring gene similar to basic transcription factor 3 Neighboring gene nuclear cap-binding protein subunit 2 pseudogene Neighboring gene TBC1 domain family, member 15 Neighboring gene RAB21, member RAS oncogene family

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
amino acid binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
tryptophan 5-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aromatic amino acid family metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to lithium ion IEP
Inferred from Expression Pattern
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tryptophan 5-hydroxylase 2
Names
neuronal tryptophan hydroxylase
tryptophan 5-monooxygenase 2
NP_776211.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173839.2NP_776211.1  tryptophan 5-hydroxylase 2

    See identical proteins and their annotated locations for NP_776211.1

    Status: PROVISIONAL

    Source sequence(s)
    AY098915
    UniProtKB/Swiss-Prot
    Q8CGU9
    Related
    ENSRNOP00000005157, ENSRNOT00000005157
    Conserved Domains (3) summary
    TIGR01270
    Location:48480
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:59132
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:147477
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    58042279..58149220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594904.1XP_017450393.1  tryptophan 5-hydroxylase 2 isoform X2

  2. XM_008765357.2XP_008763579.1  tryptophan 5-hydroxylase 2 isoform X1

    Conserved Domains (3) summary
    TIGR01270
    Location:48483
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:59132
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:150480
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    47478282..47582240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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