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RFESD Rieske Fe-S domain containing [ Homo sapiens (human) ]

Gene ID: 317671, updated on 26-Oct-2022

Summary

Official Symbol
RFESDprovided by HGNC
Official Full Name
Rieske Fe-S domain containingprovided by HGNC
Primary source
HGNC:HGNC:29587
See related
Ensembl:ENSG00000175449 AllianceGenome:HGNC:29587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.0), bone marrow (RPKM 2.4) and 24 other tissues See more
Orthologs
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Genomic context

See RFESD in Genome Data Viewer
Location:
5q15
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (95646777..95658082)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (96147700..96159005)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (94982481..94993786)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2204 Neighboring gene uncharacterized LOC112267933 Neighboring gene G protein-coupled receptor 150 Neighboring gene spermatogenesis associated 9 Neighboring gene uncharacterized LOC105379090 Neighboring gene Rho related BTB domain containing 3 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 11

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
Rieske domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131065.1NP_001124537.1  Rieske domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001124537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC035110, BC048979, BM263054, BX114571
    Consensus CDS
    CCDS47248.1
    UniProtKB/Swiss-Prot
    Q8TAC1
    Related
    ENSP00000413592.1, ENST00000458310.1
    Conserved Domains (1) summary
    cd03467
    Location:71149
    Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
  2. NM_001131066.2NP_001124538.1  Rieske domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001124538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC008547, BC035110, BI551847, BX114571, DN914641
    Consensus CDS
    CCDS47248.1
    UniProtKB/Swiss-Prot
    Q8TAC1
    Related
    ENSP00000369341.4, ENST00000380005.9
    Conserved Domains (1) summary
    cd03467
    Location:71149
    Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
  3. NM_001375394.1NP_001362323.1  Rieske domain-containing protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008547
    Consensus CDS
    CCDS4075.1
    UniProtKB/Swiss-Prot
    J3KPH1
    UniProtKB/TrEMBL
    A0A024RAR3
    Conserved Domains (1) summary
    cd03467
    Location:1896
    Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
  4. NM_173362.3NP_775498.1  Rieske domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_775498.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, compared to variant 1, that results in the use of an in-frame downstream start codon. The encoded protein (isoform 2) is has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC035110, BC048979, BX114571
    Consensus CDS
    CCDS4075.1
    UniProtKB/Swiss-Prot
    J3KPH1, Q8TAC1
    UniProtKB/TrEMBL
    A0A024RAR3
    Related
    ENSP00000309229.4, ENST00000311364.8
    Conserved Domains (1) summary
    cd03467
    Location:1896
    Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    95646777..95658082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009413.2XP_016864902.1  Rieske domain-containing protein isoform X1

    UniProtKB/Swiss-Prot
    Q8TAC1
    Conserved Domains (1) summary
    cd03467
    Location:71149
    Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
  2. XM_011543360.3XP_011541662.1  Rieske domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011541662.1

    UniProtKB/Swiss-Prot
    Q8TAC1
    Conserved Domains (1) summary
    cd03467
    Location:71149
    Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
  3. XM_047417137.1XP_047273093.1  Rieske domain-containing protein isoform X2

    UniProtKB/Swiss-Prot
    J3KPH1
    UniProtKB/TrEMBL
    A0A024RAR3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    96147700..96159005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)