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DNAJC6 DnaJ heat shock protein family (Hsp40) member C6 [ Bos taurus (domestic cattle) ]

Gene ID: 317659, updated on 5-Sep-2025
Official Symbol
DNAJC6provided by VGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C6provided by VGNC
Primary source
VGNC:VGNC:55167
See related
BGD:BT16589; EnsemblRapid:ENSBTAG00070001777
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
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See DNAJC6 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (79928527..80107442, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene leptin receptor overlapping transcript Neighboring gene adenylate kinase 4 Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene transfer RNA glutamic acid (anticodon UUC)

Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Massol RH, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798879, Free PMC Article
  2. Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface. Jiang J, et al. Biochemistry, 2003 May 20. PMID 12741832
  3. Letter to the editor: 1H, 15N, and 13C NMR backbone assignments and secondary structure of the C-terminal recombinant fragment of auxilin including the J-domain. Han CJ, et al. J Biomol NMR, 2000 Jul. PMID 10959640
  4. Primary structure of the neuronal clathrin-associated protein auxilin and its expression in bacteria. Schröder S, et al. Eur J Biochem, 1995 Mar 1. PMID 7705342
  5. Recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis. Lee DW, et al. J Cell Sci, 2006 Sep 1. PMID 16895969

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that anionic lipids (such as phosphatidylinositol phosphates) play crucial role in localization of peripheral membrane proteins (such as auxilin-1, PTEN [phosphatase and tensin homolog], and talin-1). [review-like article]
    Title: Interactions of peripheral proteins with model membranes as viewed by molecular dynamics simulations.
  2. Structure of clathrin coat with bound Hsc70 and auxilin.
    Title: Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
  3. Coats assembled from recombinant clathrin are good substrates for ATP- and auxilin-dependent, Hsc70-catalyzed uncoating.
    Title: A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction.
  4. timing of auxilin recruitment determines the onset of uncoating
    Title: A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating.
  5. Results describe the recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis.
    Title: Recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis.
  6. Auxilin binding produces a local change in heavy-chain contacts, creating a detectable global distortion of the clathrin coat [auxilin]
    Title: Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic vesicle uncoating IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
auxilin
Names
DnaJ (Hsp40) homolog, subfamily C, member 6
dnaJ homolog subfamily C member 6
putative tyrosine-protein phosphatase auxilin
NP_777261.1
XP_005204505.1
XP_005204506.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174836.2 → NP_777261.1  auxilin

    See identical proteins and their annotated locations for NP_777261.1

    Status: PROVISIONAL

    Source sequence(s)
    U09237
    UniProtKB/Swiss-Prot
    Q27974
    UniProtKB/TrEMBL
    A0A3Q1LZZ6
    Related
    ENSBTAP00070002311.1, ENSBTAT00070004134.1
    Conserved Domains (2) summary
    cd06257
    Location:858 → 903
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:223 → 361
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    79928527..80107442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005204448.4 → XP_005204505.1  auxilin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LZZ6, A0A3Q1MAH6
    Related
    ENSBTAP00070002314.1, ENSBTAT00070004141.1
    Conserved Domains (2) summary
    cd06257
    Location:892 → 937
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:257 → 395
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  2. XM_005204449.5 → XP_005204506.1  auxilin isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LZH5, A0A3Q1LZZ6
    Related
    ENSBTAP00070002312.1, ENSBTAT00070004137.1
    Conserved Domains (2) summary
    cd06257
    Location:861 → 906
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:226 → 364
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27974.1 GenPept UniProtKB/Swiss-Prot:Q27974

Gene LinkOut

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