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Rpl13a ribosomal protein L13A [ Rattus norvegicus (Norway rat) ]

Gene ID: 317646, updated on 7-Apr-2025

Summary

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Official Symbol
Rpl13aprovided by RGD
Official Full Name
ribosomal protein L13Aprovided by RGD
Primary source
RGD:628697
See related
EnsemblRapid:ENSRNOG00000084489 AllianceGenome:RGD:628697
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Involved in cellular response to UV-B; cellular response to cAMP; and cellular response to gamma radiation. Located in ribosome. Part of cytosolic large ribosomal subunit. Orthologous to human RPL13A (ribosomal protein L13a). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Spleen (RPKM 6716.4), Thymus (RPKM 5221.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rpl13a in Genome Data Viewer
Location:
1q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104746223..104748975, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95609374..95612557, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101120325..101123401, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene microRNA 150 Neighboring gene small nucleolar RNA, C/D box 35B Neighboring gene ribosomal protein S11 Neighboring gene small nucleolar RNA SNORD34 Neighboring gene small nucleolar RNA Z195/SNORD33/SNORD32 family Neighboring gene small nucleolar RNA, C/D box 35A Neighboring gene small nucleolar RNA, C/D box 33 Neighboring gene Fms related receptor tyrosine kinase 3 ligand Neighboring gene aldehyde dehydrogenase 16 family, member A1 Neighboring gene PIH1 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Copy-number variation of housekeeping gene rpl13a in rat strains selected for nervous system excitability. Kalendar R, et al. Mol Cell Probes, 2017 Jun. PMID 28192165
  2. A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum- transplantation antigen P198. Chan YL, et al. J Biol Chem, 1994 Feb 25. PMID 8119894
  3. UVB and gamma-radiation induce the expression of mRNAs encoding the ribosomal subunit L13A in rat keratinocytes. Shahmolky N, et al. Photochem Photobiol, 1999 Sep. PMID 10483362
  4. L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control. Kapasi P, et al. Mol Cell, 2007 Jan 12. PMID 17218275, Free PMC Article
  5. EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal stem cells. Curtis KM, et al. BMC Mol Biol, 2010 Aug 17. PMID 20716364, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV-B IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to gamma radiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostatic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of formation of translation preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of formation of translation preinitiation complex ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GAIT complex ISO
Inferred from Sequence Orthology
more info
  
part_of GAIT complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL13
Names
60S ribosomal protein L13a
neuroprotective protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173340.2 → NP_775462.2  large ribosomal subunit protein uL13

    See identical proteins and their annotated locations for NP_775462.2

    Status: PROVISIONAL

    Source sequence(s)
    BC086382
    UniProtKB/Swiss-Prot
    P35427
    UniProtKB/TrEMBL
    A6JAX5, B3SVE8, Q5RK10
    Related
    ENSRNOP00000027976.4, ENSRNOT00000027976.8
    Conserved Domains (1) summary
    PTZ00068
    Location:6 → 191
    PTZ00068; 60S ribosomal protein L13a; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104746223..104748975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005487745.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35427.2 GenPept UniProtKB/Swiss-Prot:P35427