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ONECUT1 one cut homeobox 1 [ Homo sapiens (human) ]

Gene ID: 3175, updated on 3-Jun-2018
Official Symbol
ONECUT1provided by HGNC
Official Full Name
one cut homeobox 1provided by HGNC
Primary source
HGNC:HGNC:8138
See related
Ensembl:ENSG00000169856 MIM:604164; Vega:OTTHUMG00000131899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNF6; HNF-6; HNF6A
Summary
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Biased expression in liver (RPKM 2.0), gall bladder (RPKM 1.7) and 2 other tissues See more
Orthologs
See ONECUT1 in Genome Data Viewer
Location:
15q21.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (52755053..52790264, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (53049160..53082209, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cAMP regulated phosphoprotein 19 Neighboring gene family with sequence similarity 214 member A Neighboring gene uncharacterized LOC105370821 Neighboring gene uncharacterized LOC105370824 Neighboring gene uncharacterized LOC101928499 Neighboring gene uncharacterized LOC107983981

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of one cut homeobox 1 (ONECUT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IEA
Inferred from Electronic Annotation
more info
 
endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
endoderm development IEA
Inferred from Electronic Annotation
more info
 
epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
spleen development IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
hepatocyte nuclear factor 6
Names
hepatocyte nuclear factor 6, alpha
one cut domain family member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004498.3NP_004489.1  hepatocyte nuclear factor 6

    See identical proteins and their annotated locations for NP_004489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AA699732, AC016044, BM679470, U96173
    Consensus CDS
    CCDS10150.1
    UniProtKB/Swiss-Prot
    Q9UBC0
    Related
    ENSP00000302630.4, OTTHUMP00000162725, ENST00000305901.6
    Conserved Domains (2) summary
    smart00389
    Location:385440
    HOX; Homeodomain
    pfam02376
    Location:288362
    CUT; CUT domain

RNA

  1. NR_073510.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA699732, AC016044, BM679470, BX118406, U96173

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    52755053..52790264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521487.2XP_011519789.1  hepatocyte nuclear factor 6 isoform X1

    Conserved Domains (1) summary
    pfam02376
    Location:288362
    CUT; CUT domain

RNA

  1. XR_001751239.1 RNA Sequence

  2. XR_931800.2 RNA Sequence

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