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Smox Smad on X [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31738, updated on 10-May-2024

Summary

Official Symbol
Smoxprovided by FlyBase
Official Full Name
Smad on Xprovided by FlyBase
Primary source
FLYBASE:FBgn0025800
Locus tag
Dmel_CG2262
See related
AllianceGenome:FB:FBgn0025800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp
Summary
Enables chromatin DNA binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; nervous system development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytosol and nucleus. Part of heteromeric SMAD protein complex. Is expressed in several structures, including central nervous system; embryonic/larval muscle cell; germline cell; gut section; and mesoderm. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; cervical cancer; ovarian cancer; and pancreatic cancer. Orthologous to several human genes including SMAD3 (SMAD family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Smox in Genome Data Viewer
Location:
7D14-7D15; 1-22 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8137041..8142279, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8031074..8036312, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene cypher Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phenylalanyl-tRNA synthetase, alpha-subunit

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in R8 cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in activin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_positive_effect determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of imaginal disc-derived wing size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse structure or activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heteromeric SMAD protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
smad on X
Names
CG2262-PA
CG2262-PB
Smox-PA
Smox-PB
Smox/dSmad2
sisters against dpp
temporarily deranged

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8137041..8142279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298077.1NP_001285006.1  smad on X, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285006.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96660, Q9TZQ2
    Conserved Domains (2) summary
    cd10488
    Location:7130
    MH1_R-SMAD; N-terminal Mad Homology 1 (MH1) domain of receptor regulated SMADs
    cd10985
    Location:285475
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
  2. NM_078524.4NP_511079.1  smad on X, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511079.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96660, Q9TZQ2
    Related
    FBpp0071140
    Conserved Domains (2) summary
    cd10488
    Location:7130
    MH1_R-SMAD; N-terminal Mad Homology 1 (MH1) domain of receptor regulated SMADs
    cd10985
    Location:285475
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3