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Was WASP actin nucleation promoting factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 317371, updated on 15-May-2025
Official Symbol
Wasprovided by RGD
Official Full Name
WASP actin nucleation promoting factorprovided by RGD
Primary source
RGD:1563567
See related
Ensembl:ENSRNOG00000031058 AllianceGenome:RGD:1563567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
WASP
Summary
Predicted to enable SH3 domain binding activity; enzyme binding activity; and identical protein binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; positive regulation of nucleobase-containing compound metabolic process; and regulation of actin filament organization. Predicted to act upstream of or within several processes, including actin filament polymerization; cellular response to type II interferon; and endosomal transport. Predicted to be located in several cellular components, including actin filament; phagocytic vesicle; and site of double-strand break. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome; X-linked severe congenital neutropenia; and thrombocytopenia. Orthologous to human WAS (WASP actin nucleation promoting factor). [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in Thymus (RPKM 230.7), Spleen (RPKM 214.4) and 6 other tissues See more
Orthologs
human mouse all
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See Was in Genome Data Viewer
Location:
Xq12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17077057..17085802)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14405105..14413850)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15155246..15164099)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 3 Neighboring gene WD repeat domain 13 Neighboring gene U6 spliceosomal RNA Neighboring gene SUV39H1 histone lysine methyltransferase Neighboring gene glyoxalase domain containing 5

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. Lang PA, et al. J Allergy Clin Immunol, 2013 Mar. PMID 23141740, Free PMC Article
  2. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Derry JM, et al. Cell, 1994 Aug 26. PMID 8069912
  3. Wiskott-Aldrich syndrome protein may be critical for CD8(+) T cell function following MCMV infection. Li S, et al. Cell Immunol, 2019 Apr. PMID 30981413
  4. Wiskott-Aldrich syndrome protein is needed for vaccinia virus pathogenesis. Guerra S, et al. J Virol, 2005 Feb. PMID 15681416, Free PMC Article
  5. Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1. Lafouresse F, et al. Immunology, 2012 Oct. PMID 22804504, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serine phosphorylation of WASP enhanced the ability of WASP to stimulate actin polymerization in mammalian cell lysates
    Title: Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within actin filament-based movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within actin polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of T cell antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
actin nucleation-promoting factor WAS
Names
Wiskott-Aldrich syndrome homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398747.1 → NP_001385676.1  actin nucleation-promoting factor WAS

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    B0BN43, M0RBE8
    Related
    ENSRNOP00000066881.2, ENSRNOT00000073289.5
    Conserved Domains (3) summary
    pfam00568
    Location:36 → 145
    WH1; WH1 domain
    pfam00786
    Location:237 → 294
    PBD; P21-Rho-binding domain
    cl41728
    Location:435 → 449
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    17077057..17085802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108248.1: Suppressed sequence

    Description
    NM_001108248.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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