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CG10958 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31736, updated on 4-Apr-2024

Summary

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Official Symbol
CG10958provided by FlyBase
Primary source
FLYBASE:FBgn0030004
Locus tag
Dmel_CG10958
See related
AllianceGenome:FB:FBgn0030004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10958
Summary
Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Is expressed in chordotonal neurons; embryonic head sensory system; male germline cell; sensory nervous system primordium; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 21. Orthologous to human DRC1 (dynein regulatory complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
7D12-7D13; 1-22 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8132285..8134967)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8026318..8029000)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cypher Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Smad on X Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Avidor-Reiss T, et al. Cell, 2004 May 14. PMID 15137945
  2. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
  3. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
  4. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
  5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonemal dynein complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium-dependent cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of axonemal dynein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10958-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8132285..8134967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132217.4 → NP_572445.1  uncharacterized protein Dmel_CG10958 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572445.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W3J8
    Related
    FBpp0071104
    Conserved Domains (2) summary
    pfam14772
    Location:120 → 220
    NYD-SP28; Sperm tail
    pfam14775
    Location:684 → 741
    NYD-SP28_assoc; Sperm tail C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3J8.1 Q9W3J8

Gene LinkOut

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