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orion orion [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31712, updated on 6-Jul-2026
Official Symbol
orionprovided by FlyBase
Official Full Name
orionprovided by FlyBase
Primary source
FLYBASE:FBgn0027280
Locus tag
Dmel_CG2206
See related
AllianceGenome:FB:FBgn0027280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2206; Dmel\CG2206; l(1)G0193; l(1)G0327; Orion
Summary
Enables chemokine activity. Involved in astrocyte chemotaxis; mushroom body development; and positive regulation of neuron remodeling. Is active in extracellular region. Is expressed in several structures, including adult head; anterior endoderm anlage; apoptotic amnioserosa; larval muscle cell; and trunk visceral muscle primordium. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See orion in Genome Data Viewer
Location:
7C9-7C9; 1-21 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7941478..7946908, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7835511..7840941, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S14a Neighboring gene Ribosomal protein S14b Neighboring gene Ubr3 ubiquitin ligase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms. Perron C, et al. Development, 2023 Oct 1. PMID 37767633, Free PMC Article
  2. Neuron-secreted chemokine-like Orion interacts with the glial receptor Draper during mushroom body neuronal remodeling in Drosophila. Perron C, et al. Front Cell Dev Biol, 2025. PMID 41640424, Free PMC Article
  3. Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling. Boulanger A, et al. Nat Commun, 2021 Mar 23. PMID 33758182, Free PMC Article
  4. The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons. Ji H, et al. Proc Natl Acad Sci U S A, 2023 Jun 13. PMID 37276397, Free PMC Article
  5. Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology. Pillmann H, et al. BMC Bioinformatics, 2011 Jun 30. PMID 21718515, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons.
    Title: The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chemokine activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in astrocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
orion
Names
CG2206-PA
CG2206-PB
lethal (1) G0193
orion-PA
orion-PB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7941478..7946908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132199.4 → NP_572427.1  orion, isoform A

    See identical proteins and their annotated locations for NP_572427.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3J2, Q9W3M4
    Related
    FBpp0071081
    Conserved Domains (2) summary
    COG0840
    Location:10 → 136
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    pfam16061
    Location:202 → 456
    DUF4803; Domain of unknown function (DUF4803)

  2. NM_206643.2 → NP_996366.1  orion, isoform B

    See identical proteins and their annotated locations for NP_996366.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVT8
    Conserved Domains (1) summary
    pfam16061
    Location:184 → 438
    DUF4803; Domain of unknown function (DUF4803)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KVT8 Q7KVT8
Q9W3M4 Q9W3M4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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