Format

Send to:

Choose Destination

FOXA3 forkhead box A3 [ Homo sapiens (human) ]

Gene ID: 3171, updated on 3-May-2020

Summary

Official Symbol
FOXA3provided by HGNC
Official Full Name
forkhead box A3provided by HGNC
Primary source
HGNC:HGNC:5023
See related
Ensembl:ENSG00000170608 MIM:602295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKHH3; HNF3G; TCF3G
Summary
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 21.0), stomach (RPKM 17.8) and 6 other tissues See more
Orthologs

Genomic context

See FOXA3 in Genome Data Viewer
Location:
19q13.32
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45864326..45873797)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46367518..46377055)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene radial spoke head 6 homolog A Neighboring gene symplekin Neighboring gene HNF4 motif-containing MPRA enhancer 173 Neighboring gene HNF1 motif-containing MPRA enhancer 100

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10179

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular glucose homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
hepatocyte nuclear factor 3-gamma
Names
HNF-3-gamma
HNF-3G
TCF-3G
fork head-related protein FKH H3
forkhead box protein A3
transcription factor 3G

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004497.3NP_004488.2  hepatocyte nuclear factor 3-gamma

    See identical proteins and their annotated locations for NP_004488.2

    Status: REVIEWED

    Source sequence(s)
    BC016024
    Consensus CDS
    CCDS12677.1
    UniProtKB/Swiss-Prot
    P55318
    UniProtKB/TrEMBL
    A0A024R0R3
    Related
    ENSP00000304004.1, ENST00000302177.3
    Conserved Domains (1) summary
    smart00339
    Location:117205
    FH; FORKHEAD

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45864326..45873797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center