U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ispF 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [ Thermus thermophilus HB8 ]

Gene ID: 3169480, updated on 16-Jun-2026
Gene symbol
ispF
Gene description
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Locus tag
TTH_RS09090
Gene type
protein coding
Organism
Thermus thermophilus HB8 (strain: HB8, type-material: type strain of Thermus thermophilus)
Lineage
Bacteria; Thermotogati; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus
Old locus tag
TTHA1790
Try the new Gene page
Try the new Transcripts and proteins table
Location:
chromosome: 1
Sequence:
Chromosome: 1; NC_006461.1 (1674235..1674693, complement)

Chromosome 1 - NC_006461.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene NifB/NifX family molybdenum-iron cluster-binding protein Neighboring gene cyclic pyranopterin monophosphate synthase MoaC Neighboring gene TRIC cation channel family protein Neighboring gene HD domain-containing protein Neighboring gene FUN14 domain-containing protein

Genomic Sequence:
NC_006461.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Kishida H, et al. Acta Crystallogr D Biol Crystallogr, 2003 Jan. PMID 12499535
  2. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. Narayanasamy P, et al. Chem Biol, 2010 Feb 26. PMID 20189102, Free PMC Article
  3. Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate. Herz S, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10694574, Free PMC Article

GeneRIFs: Gene References Into Functions

Preferred Names
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
WP_011228919.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006461.1 Reference assembly

    Range
    1674235..1674693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_011228919.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

    See identical proteins and their annotated locations for WP_011228919.1

    UniProtKB/Swiss-Prot
    Q5SHE0, Q8RQP5
    Conserved Domains (1) summary
    pfam02542
    Location:1 → 150
    YgbB; YgbB family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RQP5.1