U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

leuB 3-isopropylmalate dehydrogenase [ Thermus thermophilus HB8 ]

Gene ID: 3168996, updated on 12-Dec-2024
Gene symbol
leuB
Gene description
3-isopropylmalate dehydrogenase
Locus tag
TTH_RS06250
Gene type
protein coding
Organism
Thermus thermophilus HB8 (strain: HB8, type-material: type strain of Thermus thermophilus)
Lineage
Bacteria; Thermotogati; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus
Old locus tag
TTHA1230
NEW
Try the new Gene table
Try the new Transcript table
Location:
chromosome: 1
Sequence:
Chromosome: 1; NC_006461.1 (1168282..1169319)

Chromosome 1 - NC_006461.1Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene 3-isopropylmalate dehydratase large subunit Neighboring gene 3-isopropylmalate dehydratase small subunit Neighboring gene Uma2 family endonuclease Neighboring gene Uma2 family endonuclease Neighboring gene SDR family NAD(P)-dependent oxidoreductase Neighboring gene dihydroxy-acid dehydratase

Genomic Sequence:
NC_006461.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis. Palló A, et al. FEBS J, 2014 Nov. PMID 25211160
  2. Substitutions of coenzyme-binding, nonpolar residues improve the low-temperature activity of thermophilic dehydrogenases. Hayashi S, et al. Biochemistry, 2011 Oct 11. PMID 21894900
  3. Atomic level description of the domain closure in a dimeric enzyme: thermus thermophilus 3-isopropylmalate dehydrogenase. Gráczer É, et al. Mol Biosyst, 2011 May. PMID 21387033
  4. Cryocrystallography of 3-Isopropylmalate dehydrogenase from Thermus thermophilus and its chimeric enzyme. Nagata C, et al. Acta Crystallogr D Biol Crystallogr, 1996 Jul 1. PMID 15299625
  5. Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus. Qu C, et al. Acta Crystallogr D Biol Crystallogr, 2001 Feb. PMID 11173468

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structure of the isopropylmalate dehydrogenase-Mn-isopropylmalate-NADH unproductive quaternary complex.
    Title: Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis.
  2. Substitutions of coenzyme-binding, nonpolar residues improve the low-temperature activity of 3-Isopropylmalate dehydrogenases.
    Title: Substitutions of coenzyme-binding, nonpolar residues improve the low-temperature activity of thermophilic dehydrogenases.
  3. Studies suggest that Structural information on an essential bacterial enzyme that is absent in humans, such as 3-isopropylmalate dehydrogenase (IPMDH), may also have great relevance in respect to drug design.
    Title: Atomic level description of the domain closure in a dimeric enzyme: thermus thermophilus 3-isopropylmalate dehydrogenase.
  4. High similarity of time courses (both in biphasicity and in their rates) strongly suggests cooperative folding of the domains during formation of the native three-dimensional structure of 3-isopropylmalate dehydrogenase.
    Title: Symmetrical refolding of protein domains and subunits: example of the dimeric two-domain 3-isopropylmalate dehydrogenases.
Submit: New GeneRIF Correction
Preferred Names
3-isopropylmalate dehydrogenase
WP_011228534.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006461.1 Reference assembly

    Range
    1168282..1169319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_011228534.1 MULTISPECIES: 3-isopropylmalate dehydrogenase [Thermus]

    See identical proteins and their annotated locations for WP_011228534.1

    UniProtKB/Swiss-Prot
    Q5SIY4
    UniProtKB/TrEMBL
    A0A7R7YIL7
    Conserved Domains (1) summary
    TIGR00169
    Location:2 → 344
    leuB; 3-isopropylmalate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SIY4.1