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ileS isoleucine--tRNA ligase [ Thermus thermophilus HB8 ]

Gene ID: 3168241, updated on 12-Dec-2025
Gene symbol
ileS
Gene description
isoleucine--tRNA ligase
Locus tag
TTH_RS05430
Gene type
protein coding
Organism
Thermus thermophilus HB8 (strain: HB8, type-material: type strain of Thermus thermophilus)
Lineage
Bacteria; Thermotogati; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus
Old locus tag
TTHA1067
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Location:
chromosome: 1
Sequence:
Chromosome: 1; NC_006461.1 (1014024..1017155)

Chromosome 1 - NC_006461.1Genomic Context describing neighboring genes Neighboring gene bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD Neighboring gene transcription termination factor Rho Neighboring gene fructose-6-phosphate aldolase Neighboring gene M24 family metallopeptidase Neighboring gene cell division protein FtsX

Genomic Sequence:
NC_006461.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural basis for substrate recognition by the editing domain of isoleucyl-tRNA synthetase. Fukunaga R, et al. J Mol Biol, 2006 Jun 16. PMID 16697013
  2. Enzyme structure with two catalytic sites for double-sieve selection of substrate. Nureki O, et al. Science, 1998 Apr 24. PMID 9554847
  3. Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine. Fukunaga R, et al. J Biol Chem, 2004 Feb 27. PMID 14672940
  4. How does Pseudomonas fluorescens avoid suicide from its antibiotic pseudomonic acid?: Evidence for two evolutionarily distinct isoleucyl-tRNA synthetases conferring self-defense. Yanagisawa T, et al. J Biol Chem, 2003 Jul 11. PMID 12672810
  5. Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase. Nakama T, et al. J Biol Chem, 2001 Dec 14. PMID 11584022

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystallization and preliminary X-ray crystallographic study of the editing domain of Thermus thermophilus isoleucyl-tRNA synthetase
    Title: Crystallization and preliminary X-ray crystallographic study of the editing domain of Thermus thermophilus isoleucyl-tRNA synthetase complexed with pre- and post-transfer editing-substrate analogues.
  2. we determined the crystal structures of the Thermus thermophilus IleRS editing domain complexed with the substrate analogues in the pre and post-transfer modes, both at 1.7 A resolution
    Title: Structural basis for substrate recognition by the editing domain of isoleucyl-tRNA synthetase.
Submit: New GeneRIF Correction
Preferred Names
isoleucine--tRNA ligase
WP_011228416.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006461.1 Reference assembly

    Range
    1014024..1017155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_011228416.1 isoleucine--tRNA ligase

    See identical proteins and their annotated locations for WP_011228416.1

    UniProtKB/Swiss-Prot
    P56690, Q5SJE7
    Conserved Domains (1) summary
    PRK06039
    Location:1 → 1042
    ileS; isoleucyl-tRNA synthetase; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56690.2