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NR4A1 nuclear receptor subfamily 4 group A member 1 [ Homo sapiens (human) ]

Gene ID: 3164, updated on 11-Jun-2021

Summary

Official Symbol
NR4A1provided by HGNC
Official Full Name
nuclear receptor subfamily 4 group A member 1provided by HGNC
Primary source
HGNC:HGNC:7980
See related
Ensembl:ENSG00000123358 MIM:139139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77
Summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Expression
Broad expression in adrenal (RPKM 103.3), ovary (RPKM 73.7) and 19 other tissues See more
Orthologs
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Genomic context

See NR4A1 in Genome Data Viewer
Location:
12q13.13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52022832..52059507)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52416616..52453287)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene activin A receptor type 1B Neighboring gene RNA, U6 small nuclear 574, pseudogene Neighboring gene TAMALIN antisense RNA 1 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene Sharpr-MPRA regulatory region 2055 Neighboring gene uncharacterized LOC107984510 Neighboring gene NR4A1 antisense RNA Neighboring gene autophagy related 101 Neighboring gene uncharacterized LOC112268096 Neighboring gene small integral membrane protein 41 Neighboring gene olfactory receptor family 7 subfamily E member 47 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of NR4A1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
Vpr vpr HIV-1 Vpr downregulates expression of the gene coding for growth factor-inducible nuclear protein N10 in PHA-stimulated PBMC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9485

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucocorticoid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to corticotropin-releasing hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to corticotropin-releasing hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to fibroblast growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear receptor subfamily 4 group A member 1
Names
ST-59
TR3 orphan receptor
early response protein NAK1
growth factor-inducible nuclear protein N10
hormone receptor
nerve growth factor IB nuclear receptor variant 1
nuclear hormone receptor NUR/77
orphan nuclear receptor HMR
orphan nuclear receptor TR3
steroid receptor TR3
testicular receptor 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202233.2NP_001189162.1  nuclear receptor subfamily 4 group A member 1 isoform 2

    See identical proteins and their annotated locations for NP_001189162.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (2) has a shorter N-terminus compared to isoform 3.
    Source sequence(s)
    AC025259, AK297526, BG057763
    Consensus CDS
    CCDS55828.1
    UniProtKB/Swiss-Prot
    P22736
    Related
    ENSP00000353427.3, ENST00000360284.7
    Conserved Domains (2) summary
    cd07348
    Location:374611
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:278352
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. NM_001202234.2NP_001189163.1  nuclear receptor subfamily 4 group A member 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC025259, AK131566, BG057763
    Consensus CDS
    CCDS73471.1
    UniProtKB/TrEMBL
    F5GXF0, Q6ZMM6
    Related
    ENSP00000440864.1, ENST00000545748.5
    Conserved Domains (2) summary
    cd07348
    Location:415652
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:319393
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  3. NM_002135.5NP_002126.2  nuclear receptor subfamily 4 group A member 1 isoform 1

    See identical proteins and their annotated locations for NP_002126.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC025259, BC016147
    Consensus CDS
    CCDS8818.1
    UniProtKB/Swiss-Prot
    P22736
    UniProtKB/TrEMBL
    A0A024R126
    Related
    ENSP00000243050.1, ENST00000243050.5
    Conserved Domains (3) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    pfam15694
    Location:135230
    Med26_M; Mediator complex subunit 26 middle domain
  4. NM_173157.3NP_775180.1  nuclear receptor subfamily 4 group A member 1 isoform 1

    See identical proteins and their annotated locations for NP_775180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC025259, BG057763, L13740
    Consensus CDS
    CCDS8818.1
    UniProtKB/Swiss-Prot
    P22736
    UniProtKB/TrEMBL
    A0A024R126
    Related
    ENSP00000378302.1, ENST00000394825.6
    Conserved Domains (3) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    pfam15694
    Location:135230
    Med26_M; Mediator complex subunit 26 middle domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52022832..52059507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719364.4XP_006719427.1  nuclear receptor subfamily 4 group A member 1 isoform X3

    See identical proteins and their annotated locations for XP_006719427.1

    UniProtKB/Swiss-Prot
    P22736
    UniProtKB/TrEMBL
    A0A024R126
    Conserved Domains (3) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    pfam15694
    Location:135230
    Med26_M; Mediator complex subunit 26 middle domain
  2. XM_005268822.3XP_005268879.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    See identical proteins and their annotated locations for XP_005268879.1

    Conserved Domains (2) summary
    cd07348
    Location:433670
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:337411
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  3. XM_017019248.1XP_016874737.1  nuclear receptor subfamily 4 group A member 1 isoform X4

  4. XM_017019249.1XP_016874738.1  nuclear receptor subfamily 4 group A member 1 isoform X5

  5. XM_005268824.3XP_005268881.1  nuclear receptor subfamily 4 group A member 1 isoform X3

    See identical proteins and their annotated locations for XP_005268881.1

    UniProtKB/Swiss-Prot
    P22736
    UniProtKB/TrEMBL
    A0A024R126
    Conserved Domains (3) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    pfam15694
    Location:135230
    Med26_M; Mediator complex subunit 26 middle domain
  6. XM_006719363.1XP_006719426.1  nuclear receptor subfamily 4 group A member 1 isoform X3

    See identical proteins and their annotated locations for XP_006719426.1

    UniProtKB/Swiss-Prot
    P22736
    UniProtKB/TrEMBL
    A0A024R126
    Conserved Domains (3) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    pfam15694
    Location:135230
    Med26_M; Mediator complex subunit 26 middle domain
  7. XM_017019247.1XP_016874736.1  nuclear receptor subfamily 4 group A member 1 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173158.1: Suppressed sequence

    Description
    NM_173158.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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