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NR4A1 nuclear receptor subfamily 4 group A member 1 [ Homo sapiens (human) ]

Gene ID: 3164, updated on 1-Mar-2024

Summary

Official Symbol
NR4A1provided by HGNC
Official Full Name
nuclear receptor subfamily 4 group A member 1provided by HGNC
Primary source
HGNC:HGNC:7980
See related
Ensembl:ENSG00000123358 MIM:139139; AllianceGenome:HGNC:7980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77
Summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Expression
Broad expression in adrenal (RPKM 103.3), ovary (RPKM 73.7) and 19 other tissues See more
Orthologs
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Genomic context

See NR4A1 in Genome Data Viewer
Location:
12q13.13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52022832..52059503)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (51986402..52023082)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52416616..52453287)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene activin A receptor type 1B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4477 Neighboring gene RNA, U6 small nuclear 574, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52399414-52400100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52401473-52402158 Neighboring gene TAMALIN antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52402769-52403422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52403423-52404076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52404077-52404730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52404731-52405383 Neighboring gene uncharacterized LOC124902934 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4479 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52418471-52419408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52419409-52420346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4481 Neighboring gene uncharacterized LOC107984510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52445362-52445919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6389 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:52463395-52464110 Neighboring gene NR4A1 antisense RNA Neighboring gene autophagy related 101 Neighboring gene uncharacterized LOC112268096 Neighboring gene small integral membrane protein 41 Neighboring gene olfactory receptor family 7 subfamily E member 47 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of NR4A1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
Vpr vpr HIV-1 Vpr downregulates expression of the gene coding for growth factor-inducible nuclear protein N10 in PHA-stimulated PBMC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC9485

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables lipopolysaccharide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nuclear glucocorticoid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to corticotropin-releasing hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to corticotropin-releasing hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to fibroblast growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neurotransmitter secretion involved in regulation of skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in non-canonical inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
part_of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 4immunitygroup A member 1
Names
ST-59
TR3 orphan receptor
early response protein NAK1
growth factor-inducible nuclear protein N10
hormone receptor
nuclear hormone receptor NUR/77
orphan nuclear receptor HMR
orphan nuclear receptor TR3
steroid receptor TR3
testicular receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202233.2NP_001189162.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform 2

    See identical proteins and their annotated locations for NP_001189162.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (2) has a shorter N-terminus compared to isoform 3.
    Source sequence(s)
    AC025259, AK297526, BG057763
    Consensus CDS
    CCDS55828.1
    UniProtKB/TrEMBL
    Q8N3V2
    Related
    ENSP00000353427.3, ENST00000360284.7
    Conserved Domains (2) summary
    cd07348
    Location:374611
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:278352
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. NM_001202234.2NP_001189163.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC025259, AK131566, BG057763
    Consensus CDS
    CCDS73471.1
    UniProtKB/TrEMBL
    F5GXF0, Q6ZMM6
    Related
    ENSP00000440864.1, ENST00000545748.5
    Conserved Domains (2) summary
    cd07348
    Location:415652
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:319393
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  3. NM_002135.5NP_002126.2  nuclear receptor subfamily 4immunitygroup A member 1 isoform 1

    See identical proteins and their annotated locations for NP_002126.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC025259, BC016147
    Consensus CDS
    CCDS8818.1
    UniProtKB/Swiss-Prot
    B4DML7, P22736, Q15627, Q53Y00, Q6IBU8
    UniProtKB/TrEMBL
    Q8N3V2
    Related
    ENSP00000243050.1, ENST00000243050.5
    Conserved Domains (3) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    pfam15694
    Location:135230
    Med26_M; Mediator complex subunit 26 middle domain
  4. NM_173157.3NP_775180.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform 1

    See identical proteins and their annotated locations for NP_775180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC025259, BG057763, L13740
    Consensus CDS
    CCDS8818.1
    UniProtKB/Swiss-Prot
    B4DML7, P22736, Q15627, Q53Y00, Q6IBU8
    UniProtKB/TrEMBL
    Q8N3V2
    Related
    ENSP00000378302.1, ENST00000394825.6
    Conserved Domains (3) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    pfam15694
    Location:135230
    Med26_M; Mediator complex subunit 26 middle domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    52022832..52059503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268822.4XP_005268879.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X2

    See identical proteins and their annotated locations for XP_005268879.1

    UniProtKB/TrEMBL
    Q6ZMM6
    Conserved Domains (2) summary
    cd07348
    Location:433670
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:337411
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. XM_047428755.1XP_047284711.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X1

  3. XM_047428756.1XP_047284712.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X3

    UniProtKB/TrEMBL
    Q8N3V2
  4. XM_047428757.1XP_047284713.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X6

  5. XM_017019248.2XP_016874737.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X7

  6. XM_017019249.2XP_016874738.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X8

  7. XM_005268824.4XP_005268881.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X5

    See identical proteins and their annotated locations for XP_005268881.1

    UniProtKB/Swiss-Prot
    B4DML7, P22736, Q15627, Q53Y00, Q6IBU8
    UniProtKB/TrEMBL
    Q8N3V2
    Conserved Domains (3) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    pfam15694
    Location:135230
    Med26_M; Mediator complex subunit 26 middle domain
  8. XM_017019247.2XP_016874736.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X4

    UniProtKB/TrEMBL
    Q8N3V2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    51986402..52023082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371903.1XP_054227878.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X2

    UniProtKB/TrEMBL
    Q6ZMM6
  2. XM_054371906.1XP_054227881.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X7

  3. XM_054371907.1XP_054227882.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X8

  4. XM_054371905.1XP_054227880.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X5

    UniProtKB/Swiss-Prot
    B4DML7, P22736, Q15627, Q53Y00, Q6IBU8
    UniProtKB/TrEMBL
    Q8N3V2
  5. XM_054371904.1XP_054227879.1  nuclear receptor subfamily 4immunitygroup A member 1 isoform X4

    UniProtKB/TrEMBL
    Q8N3V2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173158.1: Suppressed sequence

    Description
    NM_173158.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.