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HMOX2 heme oxygenase 2 [ Homo sapiens (human) ]

Gene ID: 3163, updated on 9-Dec-2018

Summary

Official Symbol
HMOX2provided by HGNC
Official Full Name
heme oxygenase 2provided by HGNC
Primary source
HGNC:HGNC:5014
See related
Ensembl:ENSG00000103415 MIM:141251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HO-2
Summary
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Expression
Ubiquitous expression in testis (RPKM 23.0), brain (RPKM 16.1) and 25 other tissues See more
Orthologs

Genomic context

See HMOX2 in Genome Data Viewer
Location:
16p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (4474697..4510347)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4524719..4560348)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CORO7-PAM16 readthrough Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene NmrA like redox sensor 1 Neighboring gene cell death inducing p53 target 1 Neighboring gene chromosome 16 open reading frame 96 Neighboring gene SUB1 homolog, transcriptional regulator pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Heme degradation, organism-specific biosystem (from REACTOME)
    Heme degradation, organism-specific biosystemMost of the heme degraded in humans comes from hemoglobin. Approximately 6-8 grams of hemoglobin is degraded daily which is equivalent to approximately 300 milligrams of heme per day. Heme is not rec...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Iron uptake and transport, organism-specific biosystem (from REACTOME)
    Iron uptake and transport, organism-specific biosystemThe transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell ...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of porphyrins, organism-specific biosystem (from REACTOME)
    Metabolism of porphyrins, organism-specific biosystemPorphyrins are heterocyclic macrocycles, consisting of four pyrrole subunits (tetrapyrrole) linked by four methine (=CH-) bridges. The extensive conjugated porphyrin macrocycle is chromatic and the n...
  • Mineral absorption, organism-specific biosystem (from KEGG)
    Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Mineral absorption, conserved biosystem (from KEGG)
    Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Porphyrin and chlorophyll metabolism, organism-specific biosystem (from KEGG)
    Porphyrin and chlorophyll metabolism, organism-specific biosystem
    Porphyrin and chlorophyll metabolism
  • Porphyrin and chlorophyll metabolism, conserved biosystem (from KEGG)
    Porphyrin and chlorophyll metabolism, conserved biosystem
    Porphyrin and chlorophyll metabolism
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • heme degradation, organism-specific biosystem (from BIOCYC)
    heme degradation, organism-specific biosystemThe heme degradation pathway in animals ensures the recycling of iron. The first enzyme in this pathway, : HS02027-MONOMER, catayzes the opening of the tetrapyrrole macrocycle of : PROTOHEME, forming...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme oxygenase (decyclizing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme oxygenase (decyclizing) activity IDA
Inferred from Direct Assay
more info
PubMed 
heme oxygenase (decyclizing) activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular iron ion homeostasis TAS
Traceable Author Statement
more info
 
heme catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme catabolic process TAS
Traceable Author Statement
more info
 
heme oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
heme oxygenase 2
Names
heme oxygenase (decycling) 2
NP_001120676.1
NP_001120677.1
NP_001120678.1
NP_001273196.1
NP_001273197.1
NP_001273198.1
NP_001273199.1
NP_001273200.1
NP_002125.3
XP_011520775.1
XP_016878685.1
XP_016878686.1
XP_024306018.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127204.1NP_001120676.1  heme oxygenase 2 isoform b

    See identical proteins and their annotated locations for NP_001120676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
    Source sequence(s)
    BC002396, D21243, DA141643, DA694137
    Consensus CDS
    CCDS10517.1
    UniProtKB/Swiss-Prot
    P30519
    Related
    ENSP00000394103.3, ENST00000458134.7
    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase
  2. NM_001127205.1NP_001120677.1  heme oxygenase 2 isoform b

    See identical proteins and their annotated locations for NP_001120677.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
    Source sequence(s)
    BC002396, BP368949, D21243
    Consensus CDS
    CCDS10517.1
    UniProtKB/Swiss-Prot
    P30519
    Related
    ENSP00000391637.1, ENST00000414777.5
    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase
  3. NM_001127206.2NP_001120678.1  heme oxygenase 2 isoform b

    See identical proteins and their annotated locations for NP_001120678.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
    Source sequence(s)
    BC002396, BE561721
    Consensus CDS
    CCDS10517.1
    UniProtKB/Swiss-Prot
    P30519
    Related
    ENSP00000385100.2, ENST00000406590.6
    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase
  4. NM_001286267.1NP_001273196.1  heme oxygenase 2 isoform a

    See identical proteins and their annotated locations for NP_001273196.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (a).
    Source sequence(s)
    BC002396, DA141643
    Consensus CDS
    CCDS73818.1
    UniProtKB/Swiss-Prot
    P30519
    UniProtKB/TrEMBL
    A0A087WT44
    Conserved Domains (1) summary
    pfam01126
    Location:85290
    Heme_oxygenase; Heme oxygenase
  5. NM_001286268.1NP_001273197.1  heme oxygenase 2 isoform b

    See identical proteins and their annotated locations for NP_001273197.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
    Source sequence(s)
    BC002396, DA141643, DB184091
    Consensus CDS
    CCDS10517.1
    UniProtKB/Swiss-Prot
    P30519
    Related
    ENSP00000484467.1, ENST00000619913.4
    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase
  6. NM_001286269.1NP_001273198.1  heme oxygenase 2 isoform b

    See identical proteins and their annotated locations for NP_001273198.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
    Source sequence(s)
    BC002396, BP329113, DA141643
    Consensus CDS
    CCDS10517.1
    UniProtKB/Swiss-Prot
    P30519
    Related
    ENSP00000484423.1, ENST00000619528.4
    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase
  7. NM_001286270.1NP_001273199.1  heme oxygenase 2 isoform b

    See identical proteins and their annotated locations for NP_001273199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
    Source sequence(s)
    AK093388, BC002396, BP369861
    Consensus CDS
    CCDS10517.1
    UniProtKB/Swiss-Prot
    P30519
    UniProtKB/TrEMBL
    B3KSE0
    Related
    ENSP00000381595.3, ENST00000398595.7
    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase
  8. NM_001286271.1NP_001273200.1  heme oxygenase 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BC002396, BM905872, DA141643
    Consensus CDS
    CCDS66931.1
    UniProtKB/Swiss-Prot
    P30519
    Related
    ENSP00000460926.1, ENST00000575120.5
    Conserved Domains (1) summary
    pfam01126
    Location:2207
    Heme_oxygenase; Heme oxygenase
  9. NM_002134.4NP_002125.3  heme oxygenase 2 isoform b

    See identical proteins and their annotated locations for NP_002125.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
    Source sequence(s)
    BC002396, DA141643
    Consensus CDS
    CCDS10517.1
    UniProtKB/Swiss-Prot
    P30519
    Related
    ENSP00000459214.1, ENST00000570646.5
    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    4474697..4510347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023197.2XP_016878686.1  heme oxygenase 2 isoform X2

    UniProtKB/Swiss-Prot
    P30519
    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase
  2. XM_017023196.2XP_016878685.1  heme oxygenase 2 isoform X2

    UniProtKB/Swiss-Prot
    P30519
    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase
  3. XM_011522473.1XP_011520775.1  heme oxygenase 2 isoform X1

    See identical proteins and their annotated locations for XP_011520775.1

    UniProtKB/TrEMBL
    A0A087WT44
    Related
    ENSP00000477572.1, ENST00000613539.1
    Conserved Domains (1) summary
    pfam01126
    Location:85290
    Heme_oxygenase; Heme oxygenase
  4. XM_024450250.1XP_024306018.1  heme oxygenase 2 isoform X2

    Conserved Domains (1) summary
    pfam01126
    Location:31236
    Heme_oxygenase; Heme oxygenase

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187608.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    177026..212670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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