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V/P V protein;phosphoprotein [ Parainfluenza virus 5 ]

Gene ID: 3160800, updated on 16-Jun-2026
Gene symbol
V/P
Gene description
V protein;phosphoprotein
Locus tag
SPV5gp2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Parainfluenza virus 5 (strain: W3A)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae; Orthorubulavirus; Mammalian orthorubulavirus 5
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Sequence:
NC_006430.1 (1789..3092)

NC_006430.1Genomic Context describing neighboring genes Neighboring gene nucleocapsid protein Neighboring gene membrane protein Neighboring gene fusion protein

Genomic Sequence:
NC_006430.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Sumoylation of the P protein at K254 plays an important role in growth of parainfluenza virus 5. Sun D, et al. J Virol, 2011 Oct. PMID 21795356, Free PMC Article
  2. Identification of a phosphorylation site within the P protein important for mRNA transcription and growth of parainfluenza virus 5. Sun D, et al. J Virol, 2011 Aug. PMID 21680523, Free PMC Article
  3. Inhibition of interleukin-6 expression by the V protein of parainfluenza virus 5. Lin Y, et al. Virology, 2007 Nov 25. PMID 17692882, Free PMC Article
  4. Two mRNAs that differ by two nontemplated nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5. Thomas SM, et al. Cell, 1988 Sep 9. PMID 3044614, Free PMC Article
  5. Paramyxovirus-induced shutoff of host and viral protein synthesis: role of the P and V proteins in limiting PKR activation. Gainey MD, et al. J Virol, 2008 Jan. PMID 17977969, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structure of the MDA5 ATP-hydrolysis domain in complex with parainfluenzavirus 5 V protein; the V protein unfolded the ATP-hydrolysis domain of MDA5 and recognized a structural motif of MDA5 normally buried in the helicase fold leading to disruption of MDA5 ATP-hydrolysis site and prevention of RNA-bound MDA5 filament formation
    Title: Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.
  2. Using mass spectrometry analysis, the threonine residue at position 286 of P of parain fl uenza virus 5 was found phosphorylated. The phosphorylation site within the P protein has been found to play a positive role in viral mRNA synthesis and virus growth.
    Title: Identification of a phosphorylation site within the P protein important for mRNA transcription and growth of parainfluenza virus 5.
  3. Paramyxovirus 5 V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon beta induction.
    Title: Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction.
  4. The authors propose that sumoylation of the P protein at K254 regulates parainfluenza virus 5 gene expression through a host protein.
    Title: Sumoylation of the P protein at K254 plays an important role in growth of parainfluenza virus 5.
  5. the paramyxovirus P/V gene products limit induction of PKR by limiting the synthesis of aberrant viral mRNAs and double-stranded RNA and thus prevent the shutdown of translation
    Title: Paramyxovirus-induced shutoff of host and viral protein synthesis: role of the P and V proteins in limiting PKR activation.
  6. Parainfluenza virus 5 V protein interacts with Akt, a serine/threonine kinase, also known as protein kinase B.
    Title: Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses.
  7. the V protein of SV5 functions as a bipartite adaptor linking DDB1 to STAT2, which in turn binds STAT1 and presents STAT1 to the E3 ligase complex for ubiquitination and subsequent degradation.
    Title: Catalytic turnover of STAT1 allows PIV5 to dismantle the interferon-induced anti-viral state of cells.
  8. findings indicate that the V protein played a role in inhibiting IL-6 transcription in PIV5 infected cells
    Title: Inhibition of interleukin-6 expression by the V protein of parainfluenza virus 5.
Submit: New GeneRIF Correction

Miscellaneous features

  • Loc: 1789-1802 V/P transcription initiation site
  • Loc: 3081-3092 V/P transcription termination site
Preferred Names
V protein;phosphoprotein
YP_138512.1
  • editing process yields phosphoprotein via a stuttering mechanism, resulting in frameshift

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006430.1 Reference assembly

    Range
    1789..3092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_138512.1 phosphoprotein [Parainfluenza virus 5]

    See identical proteins and their annotated locations for YP_138512.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P11208
    UniProtKB/TrEMBL
    M1QTC9
    Conserved Domains (2) summary
    pfam14313
    Location:5 → 62
    Soyouz_module; N-terminal region of Paramyxovirinae phosphoprotein (P)
    cl03936
    Location:235 → 388
    MEV_P-protein-C_like; C-terminal domain of Measles virus phosphoprotein and related proteins

  2. YP_138513.1 V protein [Parainfluenza virus 5]

    See identical proteins and their annotated locations for YP_138513.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P11207
    UniProtKB/TrEMBL
    A0A6B9UIY6, M1RGS2
    Conserved Domains (2) summary
    pfam14313
    Location:5 → 62
    Soyouz_module; N-terminal region of Paramyxovirinae phosphoprotein (P)
    pfam13008
    Location:176 → 220
    zf-Paramyx-P; Zinc-binding domain of Paramyxoviridae V protein
Nucleotide Protein
Heading Accession and Version

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