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Oxsr1 oxidative stress responsive kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316064, updated on 19-Apr-2019

Summary

Official Symbol
Oxsr1provided by RGD
Official Full Name
oxidative stress responsive kinase 1provided by RGD
Primary source
RGD:1310466
See related
Ensembl:ENSRNOG00000013136
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Muscle (RPKM 210.8), Heart (RPKM 206.3) and 9 other tissues See more
Orthologs

Genomic context

See Oxsr1 in Genome Data Viewer
Location:
8q32
Exon count:
18
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127920349..128009951, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (127127110..127216712, complement)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 13 Neighboring gene similar to solute carrier family 22 (organic cation transporter), member 13 Neighboring gene 60S acidic ribosomal protein P0-like Neighboring gene uncharacterized LOC108351799 Neighboring gene MYD88, innate immune signal transduction adaptor Neighboring gene acetyl-CoA acyltransferase 1A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular hypotonic response IEA
Inferred from Electronic Annotation
more info
 
cellular hypotonic response ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
PubMed 
chemokine (C-C motif) ligand 21 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemokine (C-C motif) ligand 21 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
chemokine (C-X-C motif) ligand 12 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemokine (C-X-C motif) ligand 12 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of potassium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
osmosensory signaling pathway IEA
Inferred from Electronic Annotation
more info
 
osmosensory signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of T cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction by trans-phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction by trans-phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase OSR1
Names
oxidative-stress responsive 1
NP_001101664.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108194.1NP_001101664.1  serine/threonine-protein kinase OSR1

    See identical proteins and their annotated locations for NP_001101664.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    D3ZUC9
    Related
    ENSRNOP00000018056.5, ENSRNOT00000018056.5
    Conserved Domains (2) summary
    smart00220
    Location:17291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:15291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    127920349..128009951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    118123990..118213225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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