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Marf Mitochondrial assembly regulatory factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31581, updated on 11-Sep-2024

Summary

Official Symbol
Marfprovided by FlyBase
Official Full Name
Mitochondrial assembly regulatory factorprovided by FlyBase
Primary source
FLYBASE:FBgn0029870
Locus tag
Dmel_CG3869
See related
AllianceGenome:FB:FBgn0029870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0125274.3; CG3869; CG38869; dMarf; dMARF; Dmel\CG3869; dmfn; dMfn; dMFN; dMfn2; marf; MARF; Marf-1; mfn; Mfn; MFN; Mfn-2; mfn2; Mfn2; MFN2
Summary
Predicted to enable GTPase activity. Involved in several processes, including ecdysone biosynthetic process; mitochondrion organization; and regulation of mitochondrion organization. Located in mitochondrial outer membrane. Is expressed in several structures, including embryonic/larval gut; embryonic/larval midgut primordium; extended germ band embryo; germline cell; and pharyngeal muscle cell. Used to study Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2; and Charcot-Marie-Tooth disease type 2A2A. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to several human genes including MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
5F4-5F4; 1-16 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6365949..6370924)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6259982..6264957)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene swallow pseudogene Neighboring gene swallow Neighboring gene long non-coding RNA:CR44816 Neighboring gene Protein phosphatase V Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonal transport of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ecdysone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_negative_effect lymph gland crystal cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_negative_effect lymph gland crystal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fusion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in mitochondrion localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial envelope ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitochondrial assembly regulatory factor
Names
CG3869-PB
CG3869-PC
CG3869-PD
Marf-PB
Marf-PC
Marf-PD
drosophila mitofusin
mitochondria assembly regulatory factor
mitochondrial assembly
mitofusin
mitofusin/MARF
regulatory factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6365949..6370924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132092.3NP_572320.2  mitochondrial assembly regulatory factor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572320.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YU24
    Conserved Domains (3) summary
    cd09912
    Location:138393
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:652811
    Fzo_mitofusin; fzo-like conserved region
    cl21455
    Location:92172
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_206634.2NP_996357.1  mitochondrial assembly regulatory factor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996357.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHV7, Q7YU24, Q86DQ3, Q8T3J4, Q9W3Z9
    Conserved Domains (3) summary
    cd09912
    Location:138389
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:648807
    Fzo_mitofusin; fzo-like conserved region
    cl21455
    Location:92172
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_206635.3NP_996358.2  mitochondrial assembly regulatory factor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996358.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHV7, Q7YU24, Q86DQ3, Q8T3J4, Q9W3Z9
    Conserved Domains (3) summary
    cd09912
    Location:138389
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:648807
    Fzo_mitofusin; fzo-like conserved region
    cl21455
    Location:92172
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases