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Cep57 centrosomal protein 57 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315423, updated on 5-Feb-2026
Official Symbol
Cep57provided by RGD
Official Full Name
centrosomal protein 57provided by RGD
Primary source
RGD:1309884
See related
Ensembl:ENSRNOG00000006792 AllianceGenome:RGD:1309884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309884; 3110002l15rik
Summary
Predicted to enable fibroblast growth factor binding activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway; protein homooligomerization; and spermatid development. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and microtubule cytoskeleton. Predicted to be active in centrosome. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 2. Orthologous to human CEP57 (centrosomal protein 57). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Testes (RPKM 131.4), Thymus (RPKM 120.6) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Cep57 in Genome Data Viewer
Location:
8q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (18951179..18971205, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (10669588..10689257, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (12335430..12355425, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene mastermind-like transcriptional coactivator 2 Neighboring gene uncharacterized LOC120094078 Neighboring gene myotubularin related protein 2 Neighboring gene family with sequence similarity 76, member B Neighboring gene uncharacterized LOC134480141 Neighboring gene uncharacterized LOC134480142

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Cep57, a multidomain protein with unique microtubule and centrosomal localization domains. Momotani K, et al. Biochem J, 2008 Jun 1. PMID 18294141, Free PMC Article
  2. Tsp57: a novel gene induced during a specific stage of spermatogenesis. Kim YS, et al. Biol Reprod, 2004 Jan. PMID 12954732
  3. Translokin is an intracellular mediator of FGF-2 trafficking. Bossard C, et al. Nat Cell Biol, 2003 May. PMID 12717444
  4. Proteomic characterization of the human centrosome by protein correlation profiling. Andersen JS, et al. Nature, 2003 Dec 4. PMID 14654843
  5. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
centrosomal protein of 57 kDa
Names
centrosomal protein 57kDa
translokin

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108124.3 → NP_001101594.2  centrosomal protein of 57 kDa

    See identical proteins and their annotated locations for NP_001101594.2

    Status: VALIDATED

    Source sequence(s)
    BC168198, BI291153, CB807650
    UniProtKB/Swiss-Prot
    B4F7A7
    UniProtKB/TrEMBL
    A0A8I6A259, A6JN77
    Related
    ENSRNOP00000009318.6, ENSRNOT00000009318.8
    Conserved Domains (2) summary
    pfam06657
    Location:351 → 419
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:68 → 245
    Cep57_CLD; Centrosome localization domain of Cep57

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    18951179..18971205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242524.5 → XP_006242586.1  centrosomal protein of 57 kDa isoform X1

    See identical proteins and their annotated locations for XP_006242586.1

    UniProtKB/TrEMBL
    A0A8I6A259
    Conserved Domains (2) summary
    pfam06657
    Location:324 → 393
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:41 → 218
    Cep57_CLD; Centrosome localization domain of Cep57

  2. XM_039081340.2 → XP_038937268.1  centrosomal protein of 57 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8I6A259
    Conserved Domains (2) summary
    pfam06657
    Location:324 → 393
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:41 → 218
    Cep57_CLD; Centrosome localization domain of Cep57

  3. XM_006242523.5 → XP_006242585.1  centrosomal protein of 57 kDa isoform X1

    See identical proteins and their annotated locations for XP_006242585.1

    UniProtKB/TrEMBL
    A0A8I6A259
    Conserved Domains (2) summary
    pfam06657
    Location:324 → 393
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:41 → 218
    Cep57_CLD; Centrosome localization domain of Cep57

  4. XM_063265328.1 → XP_063121398.1  centrosomal protein of 57 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8I6A259
    Related
    ENSRNOP00000085671.1, ENSRNOT00000111369.2

  5. XM_039081342.2 → XP_038937270.1  centrosomal protein of 57 kDa isoform X2

    Conserved Domains (2) summary
    pfam06657
    Location:202 → 271
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:5 → 96
    Cep57_CLD; Centrosome localization domain of Cep57

  6. XM_039081348.2 → XP_038937276.1  centrosomal protein of 57 kDa isoform X5

    Conserved Domains (2) summary
    pfam06657
    Location:142 → 211
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:1 → 36
    Cep57_CLD; Centrosome localization domain of Cep57

  7. XM_039081341.2 → XP_038937269.1  centrosomal protein of 57 kDa isoform X3

    UniProtKB/TrEMBL
    A6JN79
    Conserved Domains (2) summary
    pfam06657
    Location:202 → 271
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:1 → 96
    Cep57_CLD; Centrosome localization domain of Cep57

  8. XM_039081343.2 → XP_038937271.1  centrosomal protein of 57 kDa isoform X4

    Conserved Domains (2) summary
    pfam06657
    Location:150 → 219
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:1 → 44
    Cep57_CLD; Centrosome localization domain of Cep57
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B4F7A7.2 GenPept UniProtKB/Swiss-Prot:B4F7A7

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