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Cdc42ep1 CDC42 effector protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315121, updated on 8-Apr-2026
Official Symbol
Cdc42ep1provided by RGD
Official Full Name
CDC42 effector protein 1provided by RGD
Primary source
RGD:1311131
See related
Ensembl:ENSRNOG00000008517 AllianceGenome:RGD:1311131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to be located in endomembrane system. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human CDC42EP1 (CDC42 effector protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Lung (RPKM 208.6), Heart (RPKM 125.8) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Cdc42ep1 in Genome Data Viewer
Location:
7q34
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112275759..112283665)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110395287..110403203)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120063256..120071154)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene caspase recruitment domain family, member 10 Neighboring gene galectin 2 Neighboring gene uncharacterized LOC134479608 Neighboring gene uncharacterized LOC120093687 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. Hirsch DS, et al. J Biol Chem, 2001 Jan 12. PMID 11035016
  2. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Joberty G, et al. Mol Cell Biol, 1999 Oct. PMID 10490598, Free PMC Article
  3. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of pseudopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
cdc42 effector protein 1
Names
CDC42 effector protein (Rho GTPase binding) 1
binder of Rho GTPases 5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079700.1 → NP_001073168.1  cdc42 effector protein 1

    See identical proteins and their annotated locations for NP_001073168.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128744
    UniProtKB/Swiss-Prot
    A1A5P0
    UniProtKB/TrEMBL
    A0A8I5ZKG9
    Conserved Domains (2) summary
    pfam14957
    Location:117 → 232
    BORG_CEP; Cdc42 effector
    cl00113
    Location:37 → 64
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112275759..112283665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594868.2 → XP_017450357.1  cdc42 effector protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A1A5P0
    UniProtKB/TrEMBL
    A0A8I5ZKG9
    Related
    ENSRNOP00000078201.2, ENSRNOT00000101077.2
    Conserved Domains (2) summary
    pfam14957
    Location:117 → 232
    BORG_CEP; Cdc42 effector
    cl00113
    Location:37 → 64
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  2. XM_017594865.3 → XP_017450354.1  cdc42 effector protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A1A5P0
    UniProtKB/TrEMBL
    A0A8I5ZKG9
    Conserved Domains (2) summary
    pfam14957
    Location:117 → 232
    BORG_CEP; Cdc42 effector
    cl00113
    Location:37 → 64
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  3. XM_017594867.3 → XP_017450356.1  cdc42 effector protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A1A5P0
    UniProtKB/TrEMBL
    A0A8I5ZKG9
    Conserved Domains (2) summary
    pfam14957
    Location:117 → 232
    BORG_CEP; Cdc42 effector
    cl00113
    Location:37 → 64
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1A5P0.1 GenPept UniProtKB/Swiss-Prot:A1A5P0

Gene LinkOut

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