Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mfngprovided by RGD
Official Full Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by RGD
Primary source: RGD:735126
See related: Ensembl:ENSRNOG00000008133 AllianceGenome:RGD:735126
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in marginal zone B cell differentiation and regulation of Notch signaling pathway. Predicted to act upstream of or within blastocyst formation and positive regulation of Notch signaling pathway. Predicted to be located in endomembrane system and membrane. Orthologous to human MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Thymus (RPKM 198.6), Lung (RPKM 130.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (112191288..112209129, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110310810..110328653, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119978981..119996824, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within blastocyst formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst formation	ISO Inferred from Sequence Orthology more info
involved_in marginal zone B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in marginal zone B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1,3-N-acetylglucosaminyltransferase manic fringe

Names: manic fringe homolog

NP_954541.1

EC 2.4.1.222

XP_017450353.1

EC 2.4.1.222

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.