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Lrp12 LDL receptor related protein 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314941, updated on 8-Apr-2026
Official Symbol
Lrp12provided by RGD
Official Full Name
LDL receptor related protein 12provided by RGD
Primary source
RGD:1304943
See related
Ensembl:ENSRNOG00000004152 AllianceGenome:RGD:1304943
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable integrin binding activity. Predicted to act upstream of or within several processes, including generation of neurons; integrin activation; and lymphocyte migration into lymphoid organs. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 28 and oculopharyngodistal myopathy 1. Orthologous to human LRP12 (LDL receptor related protein 12). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Brain (RPKM 97.8), Kidney (RPKM 37.7) and 9 other tissues See more
Orthologs
all
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See Lrp12 in Genome Data Viewer
Location:
7q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (72825979..72897308, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (70941068..71012409, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (78859784..78930850, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene dendrocyte expressed seven transmembrane protein Neighboring gene dihydropyrimidinase Neighboring gene uncharacterized LOC134479715 Neighboring gene uncharacterized LOC120093642 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 14

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization. Grote A, et al. Neurobiol Dis, 2016 Feb. PMID 26639854
  2. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. Battle MA, et al. Biochemistry, 2003 Jun 24. PMID 12809483
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within integrin activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymphocyte migration into lymphoid organs ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
low-density lipoprotein receptor-related protein 12
Names
low density lipoprotein receptor-related protein 12
low density lipoprotein-related protein 12

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134883.1 → NP_001128355.1  low-density lipoprotein receptor-related protein 12 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D3ZCF7
    Related
    ENSRNOP00000005668.4, ENSRNOT00000005668.7
    Conserved Domains (2) summary
    cd00041
    Location:47 → 158
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:451 → 485
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    72825979..72897308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241606.5 → XP_006241668.1  low-density lipoprotein receptor-related protein 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZU40
    Related
    ENSRNOP00000082423.1, ENSRNOT00000105107.2
    Conserved Domains (2) summary
    cd00041
    Location:28 → 139
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:432 → 466
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
Nucleotide Protein Strain
Heading Accession and Version

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