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HMGB1 high mobility group box 1 [ Homo sapiens (human) ]

Gene ID: 3146, updated on 9-Dec-2018

Summary

Official Symbol
HMGB1provided by HGNC
Official Full Name
high mobility group box 1provided by HGNC
Primary source
HGNC:HGNC:4983
See related
Ensembl:ENSG00000189403 MIM:163905
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMG1; HMG3; HMG-1; SBP-1
Summary
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 98.7), lymph node (RPKM 87.4) and 25 other tissues See more
Orthologs

Genomic context

See HMGB1 in Genome Data Viewer
Location:
13q12.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (30457916..30617597, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31032877..31191942, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 L5 Neighboring gene uncharacterized LOC107984577 Neighboring gene RNA binding motif protein 22 pseudogene 2 Neighboring gene microfibril associated protein 1 pseudogene 1 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 pseudogene 2 Neighboring gene ubiquitin specific peptidase like 1 Neighboring gene tRNA-Asn (GTT) 2-4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of high mobility group box 1 (HMGB1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
  • Activation of DNA fragmentation factor, organism-specific biosystem (from REACTOME)
    Activation of DNA fragmentation factor, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved, in part, through the activity of apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) (reviewed ...
  • Advanced glycosylation endproduct receptor signaling, organism-specific biosystem (from REACTOME)
    Advanced glycosylation endproduct receptor signaling, organism-specific biosystemAdvanced Glycosylation End- product-specific Receptor (AGER) also known as Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand membrane receptor belonging to the immunoglobulin supe...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis induced DNA fragmentation, organism-specific biosystem (from REACTOME)
    Apoptosis induced DNA fragmentation, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved through the activity of two apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease...
  • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
    Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Base excision repair, organism-specific biosystem (from KEGG)
    Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • Base excision repair, conserved biosystem (from KEGG)
    Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
    Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
  • DEx/H-box helicases activate type I IFN and inflammatory cytokines production, organism-specific biosystem (from REACTOME)
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production, organism-specific biosystemDHX36 and DHX9 are aspartate-glutamate-any amino acid aspartate/histidine (DExD/H) box helicase (DHX) proteins that localize in the cytosol. The DHX RNA helicases family includes a large number of pr...
  • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
    DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
  • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
    MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
  • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
    MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
  • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
  • RIP-mediated NFkB activation via ZBP1, organism-specific biosystem (from REACTOME)
    RIP-mediated NFkB activation via ZBP1, organism-specific biosystemOverexpression of human or murine ZBP1 (DAI) in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are...
  • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
    Regulation of TLR by endogenous ligand, organism-specific biosystemDiverse molecules of host-cell origin may serve as endogenous ligands of Toll-like receptors (TLRs) (Erridge C 2010; Piccinini AM & Midwood KS 2010). These molecules are known as damage-associated mo...
  • Retinoblastoma (RB) in Cancer, organism-specific biosystem (from WikiPathways)
    Retinoblastoma (RB) in Cancer, organism-specific biosystemDescribes the role of retinoblastoma (RB) gene in cancer.
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
  • TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated NF-kB activation, organism-specific biosystemThe TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in To...
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
    TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
    ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystemZ-DNA-binding protein-1 (ZBP1), also known as, DNA-dependent activator of IFN-regulatory factors (DAI) was reported to initiate innate immune responses in murine L929 cells upon stimulation by multip...
  • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    amb2 Integrin signaling, organism-specific biosystem
    amb2 Integrin signaling

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686A04236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-X-C chemokine binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding, bending IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding, bending IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA binding, bending ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA polymerase binding IDA
Inferred from Direct Assay
more info
PubMed 
RAGE receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA binding HDA PubMed 
bubble DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-dependent protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
chemoattractant activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine activity ISS
Inferred from Sequence or Structural Similarity
more info
 
damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
damaged DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
four-way junction DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
supercoiled DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA geometric change ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA ligation involved in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA topological change ISS
Inferred from Sequence or Structural Similarity
more info
 
T-helper 1 cell activation IDA
Inferred from Direct Assay
more info
PubMed 
T-helper 1 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
V(D)J recombination IDA
Inferred from Direct Assay
more info
PubMed 
activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
apoptotic DNA fragmentation TAS
Traceable Author Statement
more info
 
apoptotic cell clearance IDA
Inferred from Direct Assay
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
base-excision repair IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interleukin-7 IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin assembly IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin silencing IGI
Inferred from Genetic Interaction
more info
PubMed 
dendritic cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
developmental process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelial cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
eye development IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response to antigenic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
myeloid dendritic cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of CD4-positive, alpha-beta T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic cell clearance IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil clearance IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
plasmacytoid dendritic cell activation IEA
Inferred from Electronic Annotation
more info
 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA ligation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interferon-alpha secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-1 beta secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-1 secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-1 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mismatch repair IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of monocyte chemotactic protein-1 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 2 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 9 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vascular endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of wound healing IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell mediated immune response to tumor cell ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
regulation of restriction endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of tolerance induction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
tumor necrosis factor secretion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
alphav-beta3 integrin-HMGB1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
high mobility group protein B1
Names
Amphoterin
Sulfoglucuronyl carbohydrate binding protein
high-mobility group (nonhistone chromosomal) protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313892.1NP_001300821.1  high mobility group protein B1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AK122825, AL353648, AV763680, BC030981, CB051582
    Consensus CDS
    CCDS9335.1
    UniProtKB/Swiss-Prot
    P09429
    UniProtKB/TrEMBL
    A0A024RDR0
    Related
    ENSP00000343040.4, ENST00000339872.8
    Conserved Domains (2) summary
    pfam00505
    Location:95162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:778
    HMG_box_2; HMG-box domain
  2. NM_001313893.1NP_001300822.1  high mobility group protein B1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AK122825, AL353648
    Consensus CDS
    CCDS9335.1
    UniProtKB/Swiss-Prot
    P09429
    UniProtKB/TrEMBL
    A0A024RDR0
    Related
    ENSP00000384678.1, ENST00000405805.5
    Conserved Domains (2) summary
    pfam00505
    Location:95162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:778
    HMG_box_2; HMG-box domain
  3. NM_001363661.1NP_001350590.1  high mobility group protein B1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353648
    Consensus CDS
    CCDS86347.1
    Conserved Domains (2) summary
    pfam00505
    Location:95157
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:778
    HMG_box_2; HMG-box domain
  4. NM_002128.7NP_002119.1  high mobility group protein B1 isoform 1

    See identical proteins and their annotated locations for NP_002119.1

    Status: REVIEWED

    Source sequence(s)
    AL353648
    Consensus CDS
    CCDS9335.1
    UniProtKB/Swiss-Prot
    P09429
    UniProtKB/TrEMBL
    A0A024RDR0
    Related
    ENSP00000345347.5, ENST00000341423.9
    Conserved Domains (2) summary
    pfam00505
    Location:95162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:778
    HMG_box_2; HMG-box domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    30457916..30617597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449340.1XP_024305108.1  high mobility group protein B1 isoform X1

    Conserved Domains (2) summary
    pfam00505
    Location:95162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:778
    HMG_box_2; HMG-box domain
  2. XM_024449344.1XP_024305112.1  high mobility group protein B1 isoform X2

    Related
    ENSP00000382412.1, ENST00000399489.5
    Conserved Domains (2) summary
    pfam00505
    Location:95157
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:778
    HMG_box_2; HMG-box domain
  3. XM_024449343.1XP_024305111.1  high mobility group protein B1 isoform X2

    Related
    ENSP00000369904.1, ENST00000326004.4
    Conserved Domains (2) summary
    pfam00505
    Location:95157
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:778
    HMG_box_2; HMG-box domain
  4. XM_024449342.1XP_024305110.1  high mobility group protein B1 isoform X1

    Related
    ENSP00000382417.1, ENST00000399494.5
    Conserved Domains (2) summary
    pfam00505
    Location:95162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:778
    HMG_box_2; HMG-box domain
  5. XM_024449341.1XP_024305109.1  high mobility group protein B1 isoform X1

    Conserved Domains (2) summary
    pfam00505
    Location:95162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:778
    HMG_box_2; HMG-box domain
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