U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnp4F RNA-binding protein 4F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31448, updated on 5-Jan-2023

Summary

Go to the top of the page Help
Official Symbol
Rnp4Fprovided by FlyBase
Official Full Name
RNA-binding protein 4Fprovided by FlyBase
Primary source
FLYBASE:FBgn0014024
Locus tag
Dmel_CG3312
See related
AllianceGenome:FB:FBgn0014024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4f-rnp; 4F-rnp; CG3312; Dmel\CG3312; rnp-4f; Rnp-4F; RNP-4F
Summary
Predicted to enable mRNA binding activity. Involved in central nervous system development. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; gastrula embryo; germline cell; and gut. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rnp4F in Genome Data Viewer
Location:
4F5-4F5; 1-11 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5318928..5322696, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5212961..5216729, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene deadhead Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Something about silencing 10 Neighboring gene Minichromosome maintenance 3 Neighboring gene uncharacterized protein Neighboring gene XRCC1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. 5'-UTR mediated translational control of splicing assembly factor RNP-4F expression during development of the Drosophila central nervous system. Chen J, et al. Gene, 2013 Oct 10. PMID 23892091
  2. The evolution of single-copy Drosophila nuclear 4f-rnp genes: spliceosomal intron losses create polymorphic alleles. Feiber AL, et al. J Mol Evol, 2002 Oct. PMID 12355261
  3. RNA editing and alternative splicing generate mRNA transcript diversity from the Drosophila 4f-rnp locus. Petschek JP, et al. Gene, 1997 Dec 19. PMID 9434193
  4. Spatial and temporal expression of 4f-rnp gene in Drosophila melanogaster. Hess KA, et al. Differentiation, 1996 Dec. PMID 8983176
  5. RNA editing in Drosophila 4f-rnp gene nuclear transcripts by multiple A-to-G conversions. Petschek JP, et al. J Mol Biol, 1996 Jun 28. PMID 8683590

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNP-4F translational regulation is highly sensitive in the developing fly central nervous system.
    Title: 5'-UTR mediated translational control of splicing assembly factor RNP-4F expression during development of the Drosophila central nervous system.
  2. Long rnp-4f mRNA knockdown via RNAi reveals a variety of CNS abnormalities, which leads us to postulate that this isoform acts upstream of other genes which have been shown to be important for normal CNS development.
    Title: Alternative splicing of an rnp-4f mRNA isoform retaining an evolutionarily-conserved 5'-UTR intronic element is developmentally regulated and shown via RNAi to be essential for normal central nervous system development in Drosophila melanogaster.
  3. RNA editing and regulation of 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts.
    Title: RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts.
  4. model is proposed for the role of this element both in 5'-UTR alternative splicing decisions and in RNP-4F translational modulation
    Title: Alternative pre-mRNA splicing in Drosophila spliceosomal assembly factor RNP-4F during development.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
part_of ASAP complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
RNA-binding protein 4F
Names
CG3312-PA
CG3312-PB
CG3312-PD
CG3312-PF
Rnp4F-PA
Rnp4F-PB
Rnp4F-PD
Rnp4F-PF
splicing assembly factor rnp-4f

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5318928..5322696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103414.3 → NP_001096884.1  RNA-binding protein 4F, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096884.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2XP46, Q9W4D2
    UniProtKB/TrEMBL
    A8JUY0, A8JUY2
    Related
    FBpp0111789, FBtr0112876
    Conserved Domains (4) summary
    COG0724
    Location:681 → 811
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam03985
    Location:816 → 922
    Paf1; Paf1
    pfam05391
    Location:922 → 940
    Lsm_interact; Lsm interaction motif
    cl17169
    Location:722 → 802
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_206630.3 → NP_996353.1  RNA-binding protein 4F, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996353.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2XP46, Q9W4D2
    UniProtKB/TrEMBL
    A8JUY0, A8JUY2
    Related
    FBpp0089396, FBtr0070753
    Conserved Domains (4) summary
    COG0724
    Location:681 → 811
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam03985
    Location:816 → 922
    Paf1; Paf1
    pfam05391
    Location:922 → 940
    Lsm_interact; Lsm interaction motif
    cl17169
    Location:722 → 802
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_078492.4 → NP_511047.2  RNA-binding protein 4F, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511047.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2XP46, Q9W4D2
    UniProtKB/TrEMBL
    A8JUY0, A8JUY2
    Related
    FBpp0070720, FBtr0070752
    Conserved Domains (4) summary
    COG0724
    Location:681 → 811
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam03985
    Location:816 → 922
    Paf1; Paf1
    pfam05391
    Location:922 → 940
    Lsm_interact; Lsm interaction motif
    cl17169
    Location:722 → 802
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_001103413.3 → NP_001096883.3  RNA-binding protein 4F, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096883.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2XP46, Q9W4D2
    UniProtKB/TrEMBL
    A8JUY0, A8JUY2
    Related
    FBpp0309418, FBtr0340477
    Conserved Domains (4) summary
    COG0724
    Location:681 → 811
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam03985
    Location:816 → 922
    Paf1; Paf1
    pfam05391
    Location:922 → 940
    Lsm_interact; Lsm interaction motif
    cl17169
    Location:722 → 802
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JUY0 A8JUY0
Q9W4D2.1 Q9W4D2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous