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Trmt61a tRNA methyltransferase 61A [ Rattus norvegicus (Norway rat) ]

Gene ID: 314462, updated on 22-May-2022

Summary

Symbol
Trmt61aprovided by RGD
Full Name
tRNA methyltransferase 61Aprovided by RGD
Primary source
RGD:1359191
See related
Ensembl:ENSRNOG00000011398 AllianceGenome:RGD:1359191
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gcd14; Trm61; RGD1359191
Summary
Predicted to enable mRNA (adenine-N1-)-methyltransferase activity. Predicted to be involved in mRNA methylation and tRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 74.2), Brain (RPKM 50.0) and 9 other tissues See more
Orthologs
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Genomic context

See Trmt61a in Genome Data Viewer
Location:
6q32
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130737230..130743251)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136150768..136156785)

Chromosome 6 - NC_051341.1Genomic Context describing neighboring genes Neighboring gene microtubule affinity regulating kinase 3 Neighboring gene uncharacterized LOC120103628 Neighboring gene creatine kinase B Neighboring gene transfer RNA leucine (anticodon AAG) Neighboring gene BAG cochaperone 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Clone Names

  • MGC94251

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA (adenine-N1-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables mRNA (adenine-N1-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tRNA (adenine-N1-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mRNA methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of tRNA (m1A) methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Names
GCD14 and PCMT domain containing protein RGD1359191
GCD14/PCMT domain containing protein RGD1359191
mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
tRNA methyltransferase 61 homolog A
tRNA(m1A58)-methyltransferase subunit TRM61
tRNA(m1A58)-methyltransferase subunit TRMT61A
tRNA(m1A58)MTase subunit TRM61
tRNA(m1A58)MTase subunit TRMT61A
NP_001007707.1
XP_008763160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007706.1NP_001007707.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

    See identical proteins and their annotated locations for NP_001007707.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079198
    UniProtKB/Swiss-Prot
    Q6AY46
    Related
    ENSRNOP00000015308.2, ENSRNOT00000015308.4
    Conserved Domains (3) summary
    COG2519
    Location:9290
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam08704
    Location:64287
    GCD14; tRNA methyltransferase complex GCD14 subunit
    pfam14801
    Location:1258
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051341.1 Reference mRatBN7.2 Primary Assembly

    Range
    130737230..130743251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764938.3XP_008763160.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A isoform X1

    See identical proteins and their annotated locations for XP_008763160.1

    UniProtKB/Swiss-Prot
    Q6AY46
    Conserved Domains (3) summary
    COG2519
    Location:9290
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam08704
    Location:64287
    GCD14; tRNA methyltransferase complex GCD14 subunit
    pfam14801
    Location:1258
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term