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dhd deadhead [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31444, updated on 30-Nov-2022

Summary

Official Symbol
dhdprovided by FlyBase
Official Full Name
deadheadprovided by FlyBase
Primary source
FLYBASE:FBgn0011761
Locus tag
Dmel_CG4193
See related
AllianceGenome:FB:FBgn0011761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4193; CG4193; Dhd; DHD; Dmdhd; Dmeldhd; Dmel\CG4193; DmTrx-1; Trx-1
Summary
Enables disulfide oxidoreductase activity. Involved in female meiotic nuclear division; fertilization, exchange of chromosomal proteins; and head development. Located in cytosol and nucleus. Is expressed in adult head; germline cell; nurse cell; organism; and primordial germ cell. Orthologous to several human genes including TXN (thioredoxin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See dhd in Genome Data Viewer
Location:
4F4-4F4; 1-11 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5312171..5313125)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5206204..5207158)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene sans fille Neighboring gene Thioredoxin T Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Something about silencing 10 Neighboring gene RNA-binding protein 4F

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables disulfide oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm DNA decondensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
deadhead
Names
CG4193-PA
CG4193-PB
dhd-PA
dhd-PB
thioredoxin
thioredoxin-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5312171..5313125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297953.1NP_001284882.1  deadhead, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284882.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47938, Q9W4D5
    UniProtKB/TrEMBL
    A0A6P8L7N7, B4I0R1, X2JDR5
    Related
    FBpp0311766, FBtr0345745
    Conserved Domains (1) summary
    cd02947
    Location:1793
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
  2. NM_078491.3NP_511046.1  deadhead, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511046.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47938, Q9W4D5
    UniProtKB/TrEMBL
    A0A6P8L7N7, B4I0R1, X2JDR5
    Related
    FBpp0070717, FBtr0070749
    Conserved Domains (1) summary
    cd02947
    Location:1793
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...