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Uba1 ubiquitin-like modifier activating enzyme 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314432, updated on 2-May-2024

Summary

Official Symbol
Uba1provided by RGD
Official Full Name
ubiquitin-like modifier activating enzyme 1provided by RGD
Primary source
RGD:1359327
See related
Ensembl:ENSRNOG00000019164 AllianceGenome:RGD:1359327
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ube1x
Summary
Predicted to enable ubiquitin activating enzyme activity. Predicted to be involved in cellular response to DNA damage stimulus; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with bounding membrane of organelle; desmosome; and heterochromatin. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 374.7), Adrenal (RPKM 358.8) and 9 other tissues See more
Orthologs
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Genomic context

See Uba1 in Genome Data Viewer
Location:
Xq11
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (4062216..4084192, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1508700..1530677, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1723135..1745147, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 11 Neighboring gene cyclin-dependent kinase 16 Neighboring gene RNA binding motif protein 10 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin activating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in desmosome IEA
Inferred from Electronic Annotation
more info
 
located_in desmosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
part_of heterochromatin IEA
Inferred from Electronic Annotation
more info
 
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in rough endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin-like modifier-activating enzyme 1
Names
ubiquitin-activating enzyme E1, Chr X
NP_001014102.1
XP_006256674.1
XP_006256675.2
XP_063136075.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014080.1NP_001014102.1  ubiquitin-like modifier-activating enzyme 1

    See identical proteins and their annotated locations for NP_001014102.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085791
    UniProtKB/Swiss-Prot
    Q5U300
    UniProtKB/TrEMBL
    A0A8L2QII5
    Conserved Domains (1) summary
    TIGR01408
    Location:491055
    Ube1; ubiquitin-activating enzyme E1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    4062216..4084192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256613.4XP_006256675.2  ubiquitin-like modifier-activating enzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5U300
    UniProtKB/TrEMBL
    A0A8L2QII5
    Conserved Domains (1) summary
    TIGR01408
    Location:491055
    Ube1; ubiquitin-activating enzyme E1
  2. XM_006256612.5XP_006256674.1  ubiquitin-like modifier-activating enzyme 1 isoform X1

    See identical proteins and their annotated locations for XP_006256674.1

    UniProtKB/Swiss-Prot
    Q5U300
    UniProtKB/TrEMBL
    A0A8L2QII5
    Related
    ENSRNOP00000084488.1
    Conserved Domains (1) summary
    TIGR01408
    Location:491055
    Ube1; ubiquitin-activating enzyme E1
  3. XM_063280005.1XP_063136075.1  ubiquitin-like modifier-activating enzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5U300