Mboat2 membrane bound glycerophospholipid O-acyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mboat2provided by RGD
Official Full Name: membrane bound glycerophospholipid O-acyltransferase 2provided by RGD
Primary source: RGD:1305798
See related: Ensembl:ENSRNOG00000061050 AllianceGenome:RGD:1305798
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LPAAT; LPCAT; LPEAT; Oact2; LPLAT 2
Summary: Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Predicted to be involved in glycerophospholipid metabolic process; lipid modification; and regulation of chondrocyte differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Orthologous to human MBOAT2 (membrane bound O-acyltransferase domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 89.8), Kidney (RPKM 51.9) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: 6q16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (47199751..47326215)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (41471135..41597599)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (44009872..44135501)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH139119 (e-PCR)
- UniSTS:221205

AU047712 (e-PCR)
- UniSTS:110238

D6Rat207 (e-PCR), detects polymorphism
- UniSTS:228044

RH132741 (e-PCR)
- UniSTS:216024

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-alkenylglycerophosphoethanolamine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables plasmalogen synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine acyl-chain remodeling	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine acyl-chain remodeling	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: membrane-bound glycerophospholipid O-acyltransferase 2; lysophospholipid acyltransferase 2

Names: 1-acylglycerophosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; O-acyltransferase (membrane bound) domain containing 2; O-acyltransferase domain-containing protein 2; lyso-PA acyltransferase; lyso-PC acyltransferase; lyso-PC acyltransferase 4; lyso-PE acyltransferase; lysophosphatidic acid acyltransferase; lysophosphatidylcholine acyltransferase; lysophosphatidylcholine acyltransferase 4; lysophosphatidylethanolamine acyltransferase; membrane bound O-acyltransferase domain containing 2; membrane-bound O-acyltransferase domain-containing protein 2

NP_001101486.2

EC 2.3.1.23

EC 2.3.1.51

EC 2.3.1.n7

XP_006240047.1

EC 2.3.1.23

EC 2.3.1.51

EC 2.3.1.n7

XP_017449621.1

EC 2.3.1.23

EC 2.3.1.51

EC 2.3.1.n7

XP_038968139.1

EC 2.3.1.23

EC 2.3.1.51

EC 2.3.1.n7

XP_063117961.1

EC 2.3.1.23

EC 2.3.1.51

EC 2.3.1.n7

XP_063117962.1

EC 2.3.1.23

EC 2.3.1.51

EC 2.3.1.n7

XP_063117963.1

EC 2.3.1.23

EC 2.3.1.51

EC 2.3.1.n7

XP_063117964.1

EC 2.3.1.23

EC 2.3.1.51

EC 2.3.1.n7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108016.3 → NP_001101486.2 membrane-bound glycerophospholipid O-acyltransferase 2

See identical proteins and their annotated locations for NP_001101486.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q3T1J2

UniProtKB/TrEMBL

A0A8I6ATL5

Related

ENSRNOP00000075292.1, ENSRNOT00000082657.3

Conserved Domains (1) summary

cl00738
Location:13 → 474

MBOAT; MBOAT, membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

47199751..47326215

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261893.1 → XP_063117963.1 lysophospholipid acyltransferase 2 isoform X5

UniProtKB/TrEMBL

A0A8I6ATL5, A6HAY4

Related

ENSRNOP00000097782.1, ENSRNOT00000093903.2
XM_063261894.1 → XP_063117964.1 lysophospholipid acyltransferase 2 isoform X3
XM_006239985.5 → XP_006240047.1 lysophospholipid acyltransferase 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A8B3, A0A8I6ATL5

Related

ENSRNOP00000087956.1, ENSRNOT00000113515.2

Conserved Domains (1) summary

cl00738
Location:13 → 442

MBOAT; MBOAT, membrane-bound O-acyltransferase family
XM_063261892.1 → XP_063117962.1 lysophospholipid acyltransferase 2 isoform X3
XM_063261891.1 → XP_063117961.1 lysophospholipid acyltransferase 2 isoform X2

UniProtKB/TrEMBL

A6HAY5
XM_039112211.2 → XP_038968139.1 lysophospholipid acyltransferase 2 isoform X4

Conserved Domains (1) summary

cl00738
Location:2 → 323

MBOAT; membrane-bound O-acyltransferase family
XM_017594132.3 → XP_017449621.1 lysophospholipid acyltransferase 2 isoform X3