Ldah lipid droplet associated hydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ldahprovided by RGD
Official Full Name: lipid droplet associated hydrolaseprovided by RGD
Primary source: RGD:1311648
See related: Ensembl:ENSRNOG00000021475 AllianceGenome:RGD:1311648
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311648
Summary: Predicted to enable sterol ester esterase activity. Predicted to be involved in cholesterol homeostasis; intracellular triglyceride homeostasis; and lipid storage. Predicted to act upstream of with a positive effect on lipid droplet fusion. Predicted to be located in endoplasmic reticulum. Predicted to be active in lipid droplet. Orthologous to human LDAH (lipid droplet associated hydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Kidney (RPKM 93.0), Adrenal (RPKM 75.8) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 6q14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (36801359..36885929)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (31082045..31166625)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (33407223..33491726)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH131008 (e-PCR)
- UniSTS:214291

AU048419 (e-PCR)
- UniSTS:144869

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables sterol ester esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol ester esterase activity	IEA Inferred from Electronic Annotation more info
enables sterol ester esterase activity	ISO Inferred from Sequence Orthology more info
enables sterol ester esterase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular triglyceride homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet fusion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect lipid droplet fusion	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect lipid droplet fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lipid droplet-associated hydrolase

Names: UPF0554 protein C2orf43 homolog; lipid droplet-associated serine hydrolase

NP_001014097.1

EC 3.1.1.13

NP_001381198.1

EC 3.1.1.13

XP_063117952.1

EC 3.1.1.13

XP_063117953.1

EC 3.1.1.13

XP_063117954.1

EC 3.1.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014075.2 → NP_001014097.1 lipid droplet-associated hydrolase

See identical proteins and their annotated locations for NP_001014097.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q5HZX7

UniProtKB/TrEMBL

A0A8L2QK08

Conserved Domains (1) summary

pfam10230
Location:43 → 303

LIDHydrolase; Lipid-droplet associated hydrolase
NM_001394269.1 → NP_001381198.1 lipid droplet-associated hydrolase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q5HZX7

UniProtKB/TrEMBL

A0A8L2QK08

Related

ENSRNOP00000033708.6, ENSRNOT00000030244.8

Conserved Domains (1) summary

pfam10230
Location:43 → 303

LIDHydrolase; Lipid-droplet associated hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

36801359..36885929

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261883.1 → XP_063117953.1 lipid droplet-associated hydrolase isoform X2

UniProtKB/TrEMBL

A0A8I6ABK2

Related

ENSRNOP00000089371.1, ENSRNOT00000096109.2
XM_063261884.1 → XP_063117954.1 lipid droplet-associated hydrolase isoform X3
XM_063261882.1 → XP_063117952.1 lipid droplet-associated hydrolase isoform X1

UniProtKB/Swiss-Prot

Q5HZX7

UniProtKB/TrEMBL

A0A8L2QK08