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Eml4 EMAP like 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313861, updated on 5-Sep-2025
Official Symbol
Eml4provided by RGD
Official Full Name
EMAP like 4provided by RGD
Primary source
RGD:1304690
See related
Ensembl:ENSRNOG00000030294 AllianceGenome:RGD:1304690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and microtubule binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore; microtubule cytoskeleton organization; and mitotic metaphase chromosome alignment. Predicted to act upstream of or within negative regulation of microtubule depolymerization. Predicted to be located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and midbody. Predicted to colocalize with mitotic spindle. Orthologous to human EML4 (EMAP like 4). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Lung (RPKM 208.3), Spleen (RPKM 194.5) and 9 other tissues See more
Orthologs
human mouse all
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See Eml4 in Genome Data Viewer
Location:
6q12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16972054..17087365, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (11219545..11334824, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (6618370..6674550)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093197 Neighboring gene uncharacterized LOC134479098 Neighboring gene cytochrome c oxidase subunit 7A2 like Neighboring gene tumor protein, translationally-controlled 1 pseudogene 10 Neighboring gene uncharacterized LOC102556624 Neighboring gene uncharacterized LOC134479100

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Echinoderm microtubule-associated protein like protein 4, a member of the echinoderm microtubule-associated protein family, stabilizes microtubules. Houtman SH, et al. Neuroscience, 2007 Feb 23. PMID 17196341
  2. DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4. Cheng L, et al. J Mol Cell Cardiol, 2022 Aug. PMID 35659652
  3. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
echinoderm microtubule-associated protein-like 4
Names
echinoderm microtubule associated protein like 4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433946.1 → NP_001420875.1  echinoderm microtubule-associated protein-like 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2K2Z0, A0A8I6ALM1

  2. NM_001433947.1 → NP_001420876.1  echinoderm microtubule-associated protein-like 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6A8G5, A0A8I6ALM1

  3. NM_001433948.1 → NP_001420877.1  echinoderm microtubule-associated protein-like 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6H9N1, F1LT71

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    16972054..17087365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112153.2 → XP_038968081.1  echinoderm microtubule-associated protein-like 4 isoform X6

    UniProtKB/TrEMBL
    A6H9N0
    Related
    ENSRNOP00000076696.2, ENSRNOT00000118377.2
    Conserved Domains (4) summary
    sd00039
    Location:537 → 572
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:124 → 195
    HELP; HELP motif
    cd21950
    Location:6 → 64
    TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
    cl29593
    Location:401 → 762
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_039112152.2 → XP_038968080.1  echinoderm microtubule-associated protein-like 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y0M9, A6H9N1
    Conserved Domains (4) summary
    sd00039
    Location:548 → 583
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:135 → 206
    HELP; HELP motif
    cd21950
    Location:6 → 64
    TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
    cl29593
    Location:412 → 773
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_039112151.2 → XP_038968079.1  echinoderm microtubule-associated protein-like 4 isoform X4

    UniProtKB/TrEMBL
    A6H9N0
    Conserved Domains (4) summary
    sd00039
    Location:580 → 615
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:167 → 238
    HELP; HELP motif
    cd21950
    Location:6 → 64
    TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
    cl29593
    Location:444 → 805
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_039112150.2 → XP_038968078.1  echinoderm microtubule-associated protein-like 4 isoform X3

    Related
    ENSRNOP00000050319.4, ENSRNOT00000042307.6
    Conserved Domains (4) summary
    sd00039
    Location:591 → 626
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:178 → 249
    HELP; HELP motif
    cd21950
    Location:6 → 64
    TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
    cl29593
    Location:455 → 816
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_039112149.2 → XP_038968077.1  echinoderm microtubule-associated protein-like 4 isoform X2

    Related
    ENSRNOP00000087686.1, ENSRNOT00000116346.2
    Conserved Domains (4) summary
    sd00039
    Location:638 → 673
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:225 → 296
    HELP; HELP motif
    cd21950
    Location:6 → 64
    TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
    cl29593
    Location:502 → 863
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_039112148.2 → XP_038968076.1  echinoderm microtubule-associated protein-like 4 isoform X1

    Related
    ENSRNOP00000072435.2, ENSRNOT00000080013.3
    Conserved Domains (4) summary
    sd00039
    Location:649 → 684
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:236 → 307
    HELP; HELP motif
    cd21950
    Location:6 → 64
    TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
    cl29593
    Location:513 → 874
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_039112154.2 → XP_038968082.1  echinoderm microtubule-associated protein-like 4 isoform X7

    Conserved Domains (2) summary
    sd00039
    Location:315 → 350
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:179 → 540
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108008.1: Suppressed sequence

    Description
    NM_001108008.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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