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Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313811, updated on 3-Jun-2026
Official Symbol
Dnajb5provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member B5provided by RGD
Primary source
RGD:1307453
See related
Ensembl:ENSRNOG00000000130 AllianceGenome:RGD:1307453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding and response to unfolded protein. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in cytosol. Orthologous to human DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Muscle (RPKM 168.1), Brain (RPKM 82.7) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Dnajb5 in Genome Data Viewer
Location:
5q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61972637..61981887)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57176840..57186067)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58393197..58402162)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene SPATA31 subfamily F member 3 Neighboring gene PHD finger protein 24 Neighboring gene SPATA31 subfamily G member 1 Neighboring gene valosin-containing protein

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. Chen MS, et al. Gene, 1999 Oct 1. PMID 10570961
  2. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Ago T, et al. Cell, 2008 Jun 13. PMID 18555775
  3. Mapping the in vitro interactome of cardiac sodium (Na(+) )-calcium (Ca(2+) ) exchanger 1 (NCX1). Lubelwana Hafver T, et al. Proteomics, 2017 Sep. PMID 28755400
  4. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Hageman J, et al. Biochem J, 2011 Apr 1. PMID 21231916
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
involved_in response to unfolded protein ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
dnaJ homolog subfamily B member 5
Names
DnaJ (Hsp40) homolog, subfamily B, member 5
heat shock cognate 40

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108004.2 → NP_001101474.1  dnaJ homolog subfamily B member 5 isoform 2

    See identical proteins and their annotated locations for NP_001101474.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IIZ4, B2GV48, D3ZB76
    Conserved Domains (1) summary
    COG0484
    Location:34 → 377
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. NM_001415952.1 → NP_001402881.1  dnaJ homolog subfamily B member 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K9H9, B2GV48
    Related
    ENSRNOP00000075003.1, ENSRNOT00000080082.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    61972637..61981887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238072.5 → XP_006238134.1  dnaJ homolog subfamily B member 5 isoform X2

    See identical proteins and their annotated locations for XP_006238134.1

    UniProtKB/TrEMBL
    B2GV48
    Conserved Domains (1) summary
    COG0484
    Location:1 → 343
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. XM_063287843.1 → XP_063143913.1  dnaJ homolog subfamily B member 5 isoform X1

    UniProtKB/TrEMBL
    A6IIZ4, B2GV48, D3ZB76
Nucleotide Protein Strain
Heading Accession and Version

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