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Dhrs3 dehydrogenase/reductase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313689, updated on 9-Dec-2024

Summary

Official Symbol
Dhrs3provided by RGD
Official Full Name
dehydrogenase/reductase 3provided by RGD
Primary source
RGD:1305584
See related
EnsemblRapid:ENSRNOG00000015736 AllianceGenome:RGD:1305584
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in membrane. Predicted to be active in lipid droplet. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Liver (RPKM 586.1), Adrenal (RPKM 434.0) and 9 other tissues See more
Orthologs
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Genomic context

See Dhrs3 in Genome Data Viewer
Location:
5q36
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (162031853..162065655)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (156747939..156782420)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (162809090..162843385)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L9 pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC102550246 Neighboring gene vacuolar protein sorting 13 homolog D Neighboring gene ribosomal protein L36, pseudogene Neighboring gene TNF receptor superfamily member 1B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General protein information

Preferred Names
short-chain dehydrogenase/reductase 3
Names
dehydrogenase/reductase (SDR family) member 3
dehydrogenase/reductase member 2
retinal dehydrogenase/reductase family member 3
NP_001032276.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037199.3NP_001032276.3  short-chain dehydrogenase/reductase 3

    See identical proteins and their annotated locations for NP_001032276.3

    Status: PROVISIONAL

    Source sequence(s)
    BC107450
    UniProtKB/TrEMBL
    A1YR15, A6IU09, F7FCZ4, Q3B7V0
    Related
    ENSRNOP00000021155.6, ENSRNOT00000021155.7
    Conserved Domains (2) summary
    cd05339
    Location:53281
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    PRK09072
    Location:35288
    PRK09072; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    162031853..162065655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)