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Zmpste24 zinc metallopeptidase STE24 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313564, updated on 4-Jun-2020

Summary

Official Symbol
Zmpste24provided by RGD
Official Full Name
zinc metallopeptidase STE24provided by RGD
Primary source
RGD:1305570
See related
Ensembl:ENSRNOG00000012054
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Kidney (RPKM 300.5), Adrenal (RPKM 237.8) and 9 other tissues See more
Orthologs

Genomic context

See Zmpste24 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (139982404..140015541, complement)
106 current Rn_Celera (GCF_000002265.2) 5 AC_000073.1 (133182210..133213802, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (143777121..143808982, complement)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene similar to ribosomal protein L10a Neighboring gene collagen type IX alpha 2 chain Neighboring gene uncharacterized LOC108351024 Neighboring gene uncharacterized LOC108351025 Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene 40S ribosomal protein S29-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
CAAX-box protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CAMKK-AMPK signaling cascade ISO
Inferred from Sequence Orthology
more info
 
DNA repair ISO
Inferred from Sequence Orthology
more info
 
adult walking behavior ISO
Inferred from Sequence Orthology
more info
 
biological_process ND
No biological Data available
more info
 
bone mineralization ISO
Inferred from Sequence Orthology
more info
 
calcium ion import into sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle fiber development ISO
Inferred from Sequence Orthology
more info
 
cardiac ventricle development ISO
Inferred from Sequence Orthology
more info
 
cellular lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
chromatin organization ISO
Inferred from Sequence Orthology
more info
 
chromosome organization ISO
Inferred from Sequence Orthology
more info
 
determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
 
epidermis development ISO
Inferred from Sequence Orthology
more info
 
growth plate cartilage development ISO
Inferred from Sequence Orthology
more info
 
hair follicle development ISO
Inferred from Sequence Orthology
more info
 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
histone H2A phosphorylation ISO
Inferred from Sequence Orthology
more info
 
histone H2B acetylation ISO
Inferred from Sequence Orthology
more info
 
histone H2B-K5 acetylation ISO
Inferred from Sequence Orthology
more info
 
hypomethylation of CpG island ISO
Inferred from Sequence Orthology
more info
 
inflammatory cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
kidney morphogenesis ISO
Inferred from Sequence Orthology
more info
 
liver development ISO
Inferred from Sequence Orthology
more info
 
maintenance of rDNA ISO
Inferred from Sequence Orthology
more info
 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
neuromuscular process ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
 
nucleus organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
prenylated protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein processing ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA methylation ISO
Inferred from Sequence Orthology
more info
 
regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
regulation of blood circulation ISO
Inferred from Sequence Orthology
more info
 
regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
 
regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
regulation of histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
 
regulation of hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic cell cycle DNA replication ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
regulation of stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of termination of RNA polymerase I transcription ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
response to DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
 
ventricular cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CAAX prenyl protease 1 homolog
Names
zinc metallopeptidase, STE24 homolog
zinc metalloproteinase, STE24 homolog
NP_001101444.1
XP_017448887.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107974.1NP_001101444.1  CAAX prenyl protease 1 homolog

    See identical proteins and their annotated locations for NP_001101444.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    D4A5K6
    Related
    ENSRNOP00000016410.4, ENSRNOT00000016410.5
    Conserved Domains (3) summary
    COG0501
    Location:124474
    HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
    pfam01435
    Location:228471
    Peptidase_M48; Peptidase family M48
    pfam16491
    Location:41225
    Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    139982404..140015541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593398.1XP_017448887.1  CAAX prenyl protease 1 homolog isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    133182210..133213802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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