Exo5 exonuclease 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Exo5provided by RGD
Official Full Name: exonuclease 5provided by RGD
Primary source: RGD:1309802
See related: Ensembl:ENSRNOG00000037432 AllianceGenome:RGD:1309802
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dem1; RGD1309802
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity and single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in interstrand cross-link repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human EXO5 (exonuclease 5). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Spleen (RPKM 97.0), Thymus (RPKM 76.3) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 5q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (139779646..139782963, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (134494440..134497757, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (139849930..139853247, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134926 (e-PCR)
- UniSTS:218203

RH141465 (e-PCR)
- UniSTS:223459

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 4 iron, 4 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA 5'-3' DNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA 5'-3' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 5'-3' DNA exonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IEA Inferred from Electronic Annotation more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exonuclease V

Names: defects in morphology 1 homolog; defects in morphology protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.