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Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 313507, updated on 24-Apr-2022

Summary

Official Symbol
Tal1provided by RGD
Official Full Name
TAL bHLH transcription factor 1, erythroid differentiation factorprovided by RGD
Primary source
RGD:1306748
See related
Ensembl:ENSRNOG00000025051 AllianceGenome:RGD:1306748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tal-1
Summary
Predicted to enable several functions, including E-box binding activity; histone deacetylase binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Predicted to contribute to DNA binding activity. Predicted to be involved in several processes, including basophil differentiation; positive regulation of cellular component organization; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 222.3), Lung (RPKM 66.0) and 5 other tissues See more
Orthologs
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Genomic context

See Tal1 in Genome Data Viewer
Location:
5q35
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (128586776..128600976)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (133864401..133878604)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene cytidine/uridine monophosphate kinase 1 Neighboring gene STIL, centriolar assembly protein Neighboring gene uncharacterized LOC120102952 Neighboring gene PDZK1 interacting protein 1 Neighboring gene transfer RNA proline (anticodon AGG)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within astrocyte fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in basophil differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in biological_process ND
No biological Data available
more info
 
acts_upstream_of_or_within cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within definitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within generation of neurons ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemangioblast cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within megakaryocyte development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of mast cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord association neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-cell acute lymphocytic leukemia protein 1
Names
T-cell acute lymphocytic leukemia 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107958.2NP_001101428.2  T-cell acute lymphocytic leukemia protein 1

    See identical proteins and their annotated locations for NP_001101428.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000162
    UniProtKB/TrEMBL
    D3Z921
    Related
    ENSRNOP00000034958.5, ENSRNOT00000035409.6
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    128586776..128600976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238615.4XP_006238677.1  T-cell acute lymphocytic leukemia protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006238677.1

    UniProtKB/TrEMBL
    D3Z921
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  2. XM_006238618.4XP_006238680.1  T-cell acute lymphocytic leukemia protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006238680.1

    UniProtKB/TrEMBL
    D3Z921
    Related
    ENSRNOP00000071897.2, ENSRNOT00000091977.2
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  3. XM_039109984.1XP_038965912.1  T-cell acute lymphocytic leukemia protein 1 isoform X1

    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  4. XM_008763967.2XP_008762189.1  T-cell acute lymphocytic leukemia protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008762189.1

    UniProtKB/TrEMBL
    D3Z921
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  5. XM_006238617.2XP_006238679.1  T-cell acute lymphocytic leukemia protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006238679.1

    UniProtKB/TrEMBL
    D3Z921
    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  6. XM_039109985.1XP_038965913.1  T-cell acute lymphocytic leukemia protein 1 isoform X1

    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  7. XM_039109986.1XP_038965914.1  T-cell acute lymphocytic leukemia protein 1 isoform X1

    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
  8. XM_039109983.1XP_038965911.1  T-cell acute lymphocytic leukemia protein 1 isoform X1

    Conserved Domains (1) summary
    cd19706
    Location:185249
    bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins