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Cd72 Cd72 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 313498, updated on 5-Sep-2025
Official Symbol
Cd72provided by RGD
Official Full Name
Cd72 moleculeprovided by RGD
Primary source
RGD:1309757
See related
Ensembl:ENSRNOG00000017485 AllianceGenome:RGD:1309757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in negative regulation of B cell receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human CD72 (CD72 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Spleen (RPKM 249.1), Testes (RPKM 90.1) and 9 other tissues See more
Orthologs
human mouse all
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See Cd72 in Genome Data Viewer
Location:
5q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62493155..62500779, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57697361..57704980, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58943021..58950373, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ATPase, class I, type 8B, member 5 Neighboring gene uncharacterized LOC120102860 Neighboring gene RUN and SH3 domain containing 2 Neighboring gene ciliary microtubule inner protein 2B Neighboring gene uncharacterized LOC134486932 Neighboring gene testis associated actin remodelling kinase 1 Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene coiled-coil domain containing 107 Neighboring gene signaling threshold regulating transmembrane adaptor 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. Van de Velde H, et al. Nature, 1991 Jun 20. PMID 1711157
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC108873

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
B-cell differentiation antigen CD72
Names
CD72 antigen

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015016.1 → NP_001015016.1  B-cell differentiation antigen CD72

    See identical proteins and their annotated locations for NP_001015016.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091196
    UniProtKB/TrEMBL
    Q5BK59
    Related
    ENSRNOP00000057186.2, ENSRNOT00000060442.6
    Conserved Domains (2) summary
    pfam05384
    Location:124 → 220
    DegS; Sensor protein DegS
    cl02432
    Location:230 → 296
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    62493155..62500779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005504445.2 RNA Sequence

  2. XR_005504446.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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