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Tmem8b transmembrane protein 8B [ Rattus norvegicus (Norway rat) ]

Gene ID: 313490, updated on 3-Jun-2026
Official Symbol
Tmem8bprovided by RGD
Official Full Name
transmembrane protein 8Bprovided by RGD
Primary source
RGD:1310012
See related
Ensembl:ENSRNOG00000015664 AllianceGenome:RGD:1310012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310012
Summary
Predicted to be involved in cell-matrix adhesion. Predicted to be located in cell surface and plasma membrane. Orthologous to human TMEM8B (transmembrane protein 8B). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Testes (RPKM 26.0), Brain (RPKM 23.4) and 9 other tissues See more
Orthologs
all
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See Tmem8b in Genome Data Viewer
Location:
5q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62715238..62744187)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57919473..57948419)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (59165552..59193772)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 8 Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene family with sequence similarity 221, member B Neighboring gene olfactory receptor family 13 subfamily E member 8 Neighboring gene olfactory receptor family 13 subfamily J member 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. Ma J, et al. Carcinogenesis, 2005 Feb. PMID 15498789
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
transmembrane protein 8B

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427449.2 → NP_001414378.1  transmembrane protein 8B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4AD81
    Related
    ENSRNOP00000021227.7, ENSRNOT00000021227.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    62715238..62744187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111013.2 → XP_038966941.1  transmembrane protein 8B isoform X2

    UniProtKB/TrEMBL
    A6IJ47
    Conserved Domains (1) summary
    pfam12036
    Location:245 → 415
    DUF3522; Protein of unknown function (DUF3522)

  2. XM_063287726.1 → XP_063143796.1  transmembrane protein 8B isoform X2

    UniProtKB/TrEMBL
    A6IJ47

  3. XM_039111012.2 → XP_038966940.1  transmembrane protein 8B isoform X1

    UniProtKB/TrEMBL
    A0ABK0M599
    Related
    ENSRNOP00000109968.1, ENSRNOT00000153496.1
    Conserved Domains (1) summary
    pfam12036
    Location:555 → 725
    DUF3522; Protein of unknown function (DUF3522)

  4. XM_039111017.2 → XP_038966945.1  transmembrane protein 8B isoform X2

    UniProtKB/TrEMBL
    A6IJ47
    Conserved Domains (1) summary
    pfam12036
    Location:245 → 415
    DUF3522; Protein of unknown function (DUF3522)

  5. XM_063287727.1 → XP_063143797.1  transmembrane protein 8B isoform X2

    UniProtKB/TrEMBL
    A6IJ47

  6. XM_039111014.2 → XP_038966942.1  transmembrane protein 8B isoform X2

    UniProtKB/TrEMBL
    A6IJ47
    Conserved Domains (1) summary
    pfam12036
    Location:245 → 415
    DUF3522; Protein of unknown function (DUF3522)

  7. XM_063287729.1 → XP_063143799.1  transmembrane protein 8B isoform X2

    UniProtKB/TrEMBL
    A6IJ47

RNA

  1. XR_005504725.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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