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C8b complement C8 beta chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 313421, updated on 30-Sep-2021

Summary

Official Symbol
C8bprovided by RGD
Official Full Name
complement C8 beta chainprovided by RGD
Primary source
RGD:2239
See related
EnsemblRapid:ENSRNOG00000007639
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
one of three subunits of the component 8 (C8) of the complement cascade for immune response; important for formation of the Membrane Attack Complex [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 1517.6) See more
Orthologs
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Genomic context

See C8b in Genome Data Viewer
Location:
5q34
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (119535009..119572565)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (124298269..124338055)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene DAB adaptor protein 1 Neighboring gene uncharacterized LOC120103116 Neighboring gene similar to keratin complex 1, acidic, gene 18 Neighboring gene uncharacterized protein-like Neighboring gene uncharacterized LOC120102937 Neighboring gene uncharacterized LOC102547236 Neighboring gene complement C8 alpha chain

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cytolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of membrane attack complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
complement component C8 beta chain
Names
complement component 8 subunit beta
complement component 8, beta polypeptide
complement component 8, beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191759.1NP_001178688.1  complement component C8 beta chain precursor

    See identical proteins and their annotated locations for NP_001178688.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000162
    UniProtKB/Swiss-Prot
    P55314
    Related
    ENSRNOP00000010100.5, ENSRNOT00000010100.8
    Conserved Domains (3) summary
    smart00209
    Location:547589
    TSP1; Thrombospondin type 1 repeats
    smart00457
    Location:291497
    MACPF; membrane-attack complex / perforin
    pfam00057
    Location:119154
    Ldl_recept_a; Low-density lipoprotein receptor domain class A

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    119535009..119572565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109958.1XP_038965886.1  complement component C8 beta chain isoform X1

    Conserved Domains (2) summary
    smart00209
    Location:67112
    TSP1; Thrombospondin type 1 repeats
    pfam00057
    Location:119154
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
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