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Dnai4 dynein axonemal intermediate chain 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313417, updated on 10-Feb-2026
Official Symbol
Dnai4provided by RGD
Official Full Name
dynein axonemal intermediate chain 4provided by RGD
Primary source
RGD:1311027
See related
Ensembl:ENSRNOG00000006999 AllianceGenome:RGD:1311027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wdr78; RGD1311027
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in axoneme; dynein axonemal particle; and motile cilium. Predicted to be part of axonemal dynein complex. Orthologous to human DNAI4 (dynein axonemal intermediate chain 4). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Testes (RPKM 137.3), Thymus (RPKM 89.7) and 6 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Dnai4 in Genome Data Viewer
Location:
5q33
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (123016480..123105283, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (117787398..117876216, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (122551370..122642161, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene insulin like 5 Neighboring gene MIER1 transcriptional regulator Neighboring gene solute carrier family 35 member D1 Neighboring gene similar to human chromosome 1 open reading frame 141

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in axonemal dynein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of axonemal dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of axonemal dynein complex ISO
Inferred from Sequence Orthology
more info
  
part_of axonemal dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dynein axonemal particle IEA
Inferred from Electronic Annotation
more info
  
located_in dynein axonemal particle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
dynein axonemal intermediate chain 4
Names
WD repeat domain 78
WD repeat-containing protein 78
dynein intermediate chain 4, axonemal

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024786.2 → NP_001019957.1  dynein axonemal intermediate chain 4

    See identical proteins and their annotated locations for NP_001019957.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q4V8G4, Q5XIP5
    UniProtKB/TrEMBL
    A0A8I6ACQ7
    Related
    ENSRNOP00000089481.2, ENSRNOT00000115287.2
    Conserved Domains (3) summary
    COG2319
    Location:443 → 781
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:497 → 541
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:496 → 778
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    123016480..123105283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287692.1 → XP_063143762.1  dynein axonemal intermediate chain 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I6B2X4

  2. XM_063287690.1 → XP_063143760.1  dynein axonemal intermediate chain 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACQ7
    Related
    ENSRNOP00000100351.1, ENSRNOT00000127153.1

  3. XM_063287691.1 → XP_063143761.1  dynein axonemal intermediate chain 4 isoform X2

    UniProtKB/TrEMBL
    A0ABK0LLQ1
    Related
    ENSRNOP00000106569.1, ENSRNOT00000129945.1

  4. XM_008763872.3 → XP_008762094.1  dynein axonemal intermediate chain 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I6B2X4
    Related
    ENSRNOP00000095528.2, ENSRNOT00000117003.2
    Conserved Domains (3) summary
    COG2319
    Location:443 → 764
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:498 → 541
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:496 → 747
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_039109947.2 → XP_038965875.1  dynein axonemal intermediate chain 4 isoform X5

    Conserved Domains (2) summary
    COG2319
    Location:114 → 454
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:168 → 212
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8G4.1 GenPept UniProtKB/Swiss-Prot:Q4V8G4

Gene LinkOut

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