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Pigo phosphatidylinositol glycan anchor biosynthesis, class O [ Rattus norvegicus (Norway rat) ]

Gene ID: 313341, updated on 4-Jan-2025

Summary

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Official Symbol
Pigoprovided by RGD
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Oprovided by RGD
Primary source
RGD:1309498
See related
EnsemblRapid:ENSRNOG00000009930 AllianceGenome:RGD:1309498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 2. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 41.6), Thymus (RPKM 30.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pigo in Genome Data Viewer
Location:
5q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62040979..62052067, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57244721..57256252, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58461055..58470699, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene valosin-containing protein Neighboring gene FA complementation group G Neighboring gene stomatin like 2 Neighboring gene atos homolog B Neighboring gene unc-13 homolog B Neighboring gene ribosomal protein L39, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Vitamin B6-responsive epilepsy due to inherited GPI deficiency. Kuki I, et al. Neurology, 2013 Oct 15. PMID 24049131
  2. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. Hong Y, et al. J Biol Chem, 2000 Jul 7. PMID 10781593
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mannose-ethanolamine phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose-ethanolamine phosphotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GPI ethanolamine phosphate transferase 3
Names
phosphatidylinositol glycan, class O

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431175.1 → NP_001418104.1  GPI ethanolamine phosphate transferase 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D3ZTP8

  2. NM_001431176.1 → NP_001418105.1  GPI ethanolamine phosphate transferase 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D3ZTP8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    62040979..62052067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110982.1 → XP_038966910.1  GPI ethanolamine phosphate transferase 3 isoform X1

    UniProtKB/TrEMBL
    D3ZTP8
    Related
    ENSRNOP00000102008.1, ENSRNOT00000164556.1
    Conserved Domains (1) summary
    cd16023
    Location:85 → 365
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

  2. XM_039110981.2 → XP_038966909.1  GPI ethanolamine phosphate transferase 3 isoform X1

    UniProtKB/TrEMBL
    D3ZTP8
    Conserved Domains (1) summary
    cd16023
    Location:85 → 365
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

  3. XM_233141.11 → XP_233141.7  GPI ethanolamine phosphate transferase 3 isoform X2

    See identical proteins and their annotated locations for XP_233141.7

    UniProtKB/TrEMBL
    A0A8I5ZR91, D3ZTP8
    Related
    ENSRNOP00000103342.1, ENSRNOT00000124803.1
    Conserved Domains (2) summary
    COG1524
    Location:63 → 360
    Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
    cd16023
    Location:85 → 365
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

  4. XM_039110983.2 → XP_038966911.1  GPI ethanolamine phosphate transferase 3 isoform X3

    UniProtKB/TrEMBL
    D3ZTP8
    Related
    ENSRNOP00000091520.2, ENSRNOT00000118014.2
    Conserved Domains (1) summary
    cd16023
    Location:64 → 344
    GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

  5. XM_039110984.2 → XP_038966912.1  GPI ethanolamine phosphate transferase 3 isoform X5

    Conserved Domains (1) summary
    cl23718
    Location:1 → 65
    ALP_like; alkaline phosphatases and sulfatases

  6. XM_063288526.1 → XP_063144596.1  GPI ethanolamine phosphate transferase 3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A4S1
Nucleotide Protein Strain
Heading Accession and Version

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