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Rala Ras-like protein A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31332, updated on 9-Dec-2024

Summary

Official Symbol
Ralaprovided by FlyBase
Official Full Name
Ras-like protein Aprovided by FlyBase
Primary source
FLYBASE:FBgn0015286
Locus tag
Dmel_CG2849
See related
AllianceGenome:FB:FBgn0015286
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
24639550; anon-EST:fe1H4; CG2849; D-RalA; Dm RalA; Dmel\CG2849; dRal; Dral; DRal; Drala; DralA; DRala; l(1)G0174; l(1)G0373; l(1)G0501; P48555; ral; Ral; Ral-a; rala; ralA; RalA; RALA
Summary
Enables GTPase activity and PDZ domain binding activity. Involved in several processes, including R3/R4 cell fate commitment; Ras protein signal transduction; and regulation of signal transduction. Located in plasma membrane. Is expressed in several structures, including follicle cell; ganglia; gut section; imaginal disc; and outer photoreceptor cell. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to several human genes including RALA (RAS like proto-oncogene A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Rala in Genome Data Viewer
Location:
3E5-3E6; 1-4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3704610..3719635, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3598643..3613668, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Mnt Neighboring gene long non-coding RNA:CR45102 Neighboring gene Tousled-like kinase Neighboring gene mir-4962 stem loop Neighboring gene Hsc/Hsp70-interacting protein related

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Ras-like protein A
Names
CG2849-PA
CG2849-PB
CG2849-PC
Rala-PA
Rala-PB
Rala-PC
Ras-related protein
anon-fast-evolving-1H4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    3704610..3719635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080324.4NP_525063.1  Ras-like protein A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525063.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48555, Q540X1, Q9W4Q6
    Related
    FBpp0070559
    Conserved Domains (1) summary
    cd04139
    Location:12174
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
  2. NM_166985.3NP_726881.1  Ras-like protein A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726881.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q962I2
    Related
    FBpp0070557
    Conserved Domains (1) summary
    cd04139
    Location:12174
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
  3. NM_166986.3NP_726882.1  Ras-like protein A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726882.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48555, Q540X1, Q9W4Q6
    Related
    FBpp0070558
    Conserved Domains (1) summary
    cd04139
    Location:12174
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB