Kdf1 keratinocyte differentiation factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Kdf1provided by RGD
Full Name: keratinocyte differentiation factor 1provided by RGD
Primary source: RGD:1303271
See related: Ensembl:ENSRNOG00000055933 AllianceGenome:RGD:1303271
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1303271
Summary: Predicted to be involved in several processes, including positive regulation of epidermal cell differentiation; regulation of epidermal cell division; and skin epidermis development. Predicted to act upstream of or within several processes, including keratinocyte development; negative regulation of keratinocyte proliferation; and protein stabilization. Predicted to be located in cell cortex and cell leading edge. Predicted to be active in cell junction. Human ortholog(s) of this gene implicated in ectodermal dysplasia 12. Orthologous to human KDF1 (keratinocyte differentiation factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Kidney (RPKM 27.0), Lung (RPKM 16.3) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 5q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (151028152..151039753)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (145744753..145758150)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (151740902..151752863)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in developmental growth	IEA Inferred from Electronic Annotation more info
involved_in developmental growth	ISO Inferred from Sequence Orthology more info
involved_in developmental growth	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	IEA Inferred from Electronic Annotation more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in keratinocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within keratinocyte development	ISO Inferred from Sequence Orthology more info
involved_in limb epidermis development	IEA Inferred from Electronic Annotation more info
involved_in limb epidermis development	ISO Inferred from Sequence Orthology more info
involved_in limb epidermis development	ISS Inferred from Sequence or Structural Similarity more info
involved_in morphogenesis of embryonic epithelium	IEA Inferred from Electronic Annotation more info
involved_in morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of embryonic epithelium	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epidermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein deubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal cell division	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermal cell division	IEA Inferred from Electronic Annotation more info
involved_in regulation of epidermal cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal cell division	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: keratinocyte differentiation factor 1

Names: uncharacterized protein C1orf172 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004268.1 → NP_001004268.1 keratinocyte differentiation factor 1

See identical proteins and their annotated locations for NP_001004268.1

Status: PROVISIONAL

Source sequence(s)

BC079148

UniProtKB/Swiss-Prot

Q6AY88

UniProtKB/TrEMBL

A6ISX1

Related

ENSRNOP00000070982.1, ENSRNOT00000081318.3

Conserved Domains (1) summary

pfam15551
Location:48 → 397

DUF4656; Domain of unknown function (DUF4656)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

151028152..151039753

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239017.5 → XP_006239079.1 keratinocyte differentiation factor 1 isoform X1

See identical proteins and their annotated locations for XP_006239079.1

UniProtKB/Swiss-Prot

Q6AY88

UniProtKB/TrEMBL

A6ISX1

Conserved Domains (1) summary

pfam15551
Location:48 → 397

DUF4656; Domain of unknown function (DUF4656)
XM_063287532.1 → XP_063143602.1 keratinocyte differentiation factor 1 isoform X1

UniProtKB/Swiss-Prot

Q6AY88

UniProtKB/TrEMBL

A6ISX1
XM_006239016.3 → XP_006239078.1 keratinocyte differentiation factor 1 isoform X1

See identical proteins and their annotated locations for XP_006239078.1

UniProtKB/Swiss-Prot

Q6AY88

UniProtKB/TrEMBL

A6ISX1

Conserved Domains (1) summary

pfam15551
Location:48 → 397

DUF4656; Domain of unknown function (DUF4656)