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Cd163 CD163 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 312701, updated on 8-Apr-2026
Official Symbol
Cd163provided by RGD
Official Full Name
CD163 moleculeprovided by RGD
Primary source
RGD:1310382
See related
Ensembl:ENSRNOG00000010253 AllianceGenome:RGD:1310382
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ED2
Summary
Predicted to enable scaffold protein binding activity. Located in cell surface. Biomarker of traumatic brain injury and uveitis. Orthologous to human CD163 (CD163 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Spleen (RPKM 505.2), Liver (RPKM 139.0) and 5 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Cd163 in Genome Data Viewer
Location:
4q42
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (158770751..158804146)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157085080..157118470)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (156752063..156785467)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486636 Neighboring gene complement C1s, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RIKEN cDNA 1700013D24 gene like Neighboring gene uncharacterized LOC134486637

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage regulation of the "second brain": CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
    Title: Macrophage regulation of the "second brain": CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
  2. An increased number of CD163(+) chondrocytes with enhanced phagocytic activity were discovered within degraded joint cartilage, indicating a role in eliminating degraded tissues.
    Title: The identification of CD163 expressing phagocytic chondrocytes in joint cartilage and its novel scavenger role in cartilage degradation.
  3. Significant parenchymal CD163+ cell accumulation is observed two days post traumatic brain injury and continuously increased in the investigated survival time.
    Title: Lesional accumulation of CD163+ macrophages/microglia in rat traumatic brain injury.
  4. identify CD163 on macrophages as an adhesion receptor for erythroblasts in erythroblastic islands, and suggest a regulatory role for CD163 during erythropoiesis
    Title: The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor.
  5. A broadly expressed macrophage scavenger receptor that may play a role in the activation of macrophages during hemolytic and/or inflammatory conditions.
    Title: The rat macrophage scavenger receptor CD163: expression, regulation and role in inflammatory mediator production.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
scavenger receptor cysteine-rich type 1 protein M130
Names
CD163 antigen
cluster of differentiation 163

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107887.1 → NP_001101357.1  scavenger receptor cysteine-rich type 1 protein M130 precursor

    See identical proteins and their annotated locations for NP_001101357.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473964
    UniProtKB/TrEMBL
    A0ABK0LQZ7, A6ILI0, D3Z9U2
    Related
    ENSRNOP00000104317.1, ENSRNOT00000152480.1
    Conserved Domains (2) summary
    smart00202
    Location:721 → 821
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:726 → 821
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    158770751..158804146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237352.5 → XP_006237414.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JVY2, D3Z9U2
    Related
    ENSRNOP00000069665.2, ENSRNOT00000084588.3
    Conserved Domains (2) summary
    smart00202
    Location:721 → 821
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:726 → 821
    SRCR; Scavenger receptor cysteine-rich domain

  2. XM_017592650.3 → XP_017448139.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X2

    UniProtKB/TrEMBL
    D3Z9U2

  3. XM_017592651.3 → XP_017448140.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X2

    UniProtKB/TrEMBL
    D3Z9U2
    Related
    ENSRNOP00000058828.2, ENSRNOT00000068407.3
Nucleotide Protein Strain
Heading Accession and Version

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