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Tsen2 tRNA splicing endonuclease subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312649, updated on 8-Apr-2026
Official Symbol
Tsen2provided by RGD
Official Full Name
tRNA splicing endonuclease subunit 2provided by RGD
Primary source
RGD:1309946
See related
Ensembl:ENSRNOG00000060175 AllianceGenome:RGD:1309946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309946
Summary
Predicted to enable tRNA-intron lyase activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 42.8), Kidney (RPKM 35.4) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Tsen2 in Genome Data Viewer
Location:
4q42
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (150275389..150310846)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (148602805..148638219)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (147455506..147490869)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene synapsin II Neighboring gene small nucleolar RNA SNORA76 Neighboring gene peroxisome proliferator-activated receptor gamma Neighboring gene MKRN2 opposite strand Neighboring gene makorin, ring finger protein, 2 Neighboring gene Raf-1 proto-oncogene, serine/threonine kinase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Handling tRNA introns, archaeal way and eukaryotic way. Yoshihisa T. Front Genet, 2014. PMID 25071838, Free PMC Article
  2. The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs. Weitzer S, et al. Nature, 2007 May 10. PMID 17495927
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-intron lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-intron lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA splicing, via endonucleolytic cleavage and ligation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA-type intron splice site recognition and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA-type intron splice site recognition and cleavage ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of tRNA-intron endonuclease complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA-intron endonuclease complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
tRNA-splicing endonuclease subunit Sen2
Names
TSEN2 tRNA splicing endonuclease subunit
tRNA-intron endonuclease Sen2
tRNA-intron nuclease 2
NP_001014079.1
XP_008761462.1
XP_008761464.1
XP_038963566.1
XP_038963567.1
XP_063142160.1
XP_063142161.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014057.2 → NP_001014079.1  tRNA-splicing endonuclease subunit Sen2

    See identical proteins and their annotated locations for NP_001014079.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5M954
    UniProtKB/TrEMBL
    A0ABK0M1N4
    Conserved Domains (2) summary
    pfam02778
    Location:279 → 327
    tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
    cd22363
    Location:337 → 428
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    150275389..150310846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286091.1 → XP_063142161.1  tRNA-splicing endonuclease subunit Sen2 isoform X3

    UniProtKB/TrEMBL
    A6IKY7

  2. XM_008763242.4 → XP_008761464.1  tRNA-splicing endonuclease subunit Sen2 isoform X1

    See identical proteins and their annotated locations for XP_008761464.1

    UniProtKB/Swiss-Prot
    Q5M954
    UniProtKB/TrEMBL
    A0ABK0M1N4
    Conserved Domains (2) summary
    pfam02778
    Location:279 → 327
    tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
    cd22363
    Location:337 → 428
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

  3. XM_008763240.4 → XP_008761462.1  tRNA-splicing endonuclease subunit Sen2 isoform X1

    See identical proteins and their annotated locations for XP_008761462.1

    UniProtKB/Swiss-Prot
    Q5M954
    UniProtKB/TrEMBL
    A0ABK0M1N4
    Related
    ENSRNOP00000073692.1, ENSRNOT00000081957.3
    Conserved Domains (2) summary
    pfam02778
    Location:279 → 327
    tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
    cd22363
    Location:337 → 428
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

  4. XM_039107638.2 → XP_038963566.1  tRNA-splicing endonuclease subunit Sen2 isoform X2

    Conserved Domains (2) summary
    pfam02778
    Location:184 → 232
    tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
    cd22363
    Location:242 → 333
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

  5. XM_039107639.2 → XP_038963567.1  tRNA-splicing endonuclease subunit Sen2 isoform X2

    Conserved Domains (2) summary
    pfam02778
    Location:184 → 232
    tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
    cd22363
    Location:242 → 333
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

  6. XM_063286090.1 → XP_063142160.1  tRNA-splicing endonuclease subunit Sen2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M954.1 GenPept UniProtKB/Swiss-Prot:Q5M954

Gene LinkOut

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