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Atg7 autophagy related 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312647, updated on 14-May-2019

Summary

Official Symbol
Atg7provided by RGD
Official Full Name
autophagy related 7provided by RGD
Primary source
RGD:1304817
See related
Ensembl:ENSRNOG00000007486
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Apg7l
Expression
Biased expression in Adrenal (RPKM 46.7), Thymus (RPKM 44.3) and 9 other tissues See more
Orthologs

Genomic context

See Atg7 in Genome Data Viewer
Location:
4q42
Exon count:
21
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (146570113..146777093)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (209861459..210067618)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene endothelial differentiation-related factor 1-like Neighboring gene tubulin alpha-1C chain-like Neighboring gene endogenous retrovirus group K member 10 Gag polyprotein-like Neighboring gene vestigial-like family member 4 Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

  • Homologs of the Atg7 gene: The Atg7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 268 organisms have orthologs with human gene Atg7
  • Orthologs

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Atg12 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Atg12 activating enzyme activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Atg12 activating enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Atg8 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Atg8 activating enzyme activity ISO
Inferred from Sequence Orthology
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
C-terminal protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adult walking behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
amino acid homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
autophagy ISO
Inferred from Sequence Orthology
more info
PubMed 
autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
autophagy of host cells involved in interaction with symbiont IEA
Inferred from Electronic Annotation
more info
 
autophagy of host cells involved in interaction with symbiont ISO
Inferred from Sequence Orthology
more info
PubMed 
autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hyperoxia ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hyperoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to morphine IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to starvation ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular sphingolipid homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
central nervous system neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
cerebellar Purkinje cell layer development ISO
Inferred from Sequence Orthology
more info
PubMed 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
PubMed 
chaperone-mediated autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
defense response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
late nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
liver development ISO
Inferred from Sequence Orthology
more info
PubMed 
macroautophagy ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane organization ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of oxidative stress-induced neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of sphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative stranded viral RNA replication ISO
Inferred from Sequence Orthology
more info
PubMed 
nervous system process ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron projection development ISO
Inferred from Sequence Orthology
more info
PubMed 
organelle organization ISO
Inferred from Sequence Orthology
more info
PubMed 
piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mucus secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein modification process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein modification process ISO
Inferred from Sequence Orthology
more info
PubMed 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
PubMed 
protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
protein lipidation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein modification by small protein conjugation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
pyramidal neuron development ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell development ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of hemopoiesis ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
PubMed 
response to fluoride IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to starvation ISO
Inferred from Sequence Orthology
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
suppression by virus of host autophagy IEA
Inferred from Electronic Annotation
more info
 
suppression by virus of host autophagy ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axoneme ISO
Inferred from Sequence Orthology
more info
PubMed 
axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-like modifier-activating enzyme ATG7
Names
ATG12-activating enzyme E1 ATG7
ATG7 autophagy related 7 homolog
autophagy 7-like
autophagy related 7 homolog
autophagy-related protein 7
ubiquitin-activating enzyme E1-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012097.1NP_001012097.1  ubiquitin-like modifier-activating enzyme ATG7

    See identical proteins and their annotated locations for NP_001012097.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082059
    UniProtKB/Swiss-Prot
    Q641Y5
    Related
    ENSRNOP00000063617.1, ENSRNOT00000067532.2
    Conserved Domains (3) summary
    cd01486
    Location:353677
    Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    TIGR01381
    Location:11697
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    pfam16420
    Location:9316
    ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    146570113..146777093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237033.3XP_006237095.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X2

    See identical proteins and their annotated locations for XP_006237095.1

    UniProtKB/Swiss-Prot
    Q641Y5
    Conserved Domains (3) summary
    cd01486
    Location:353677
    Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    TIGR01381
    Location:11697
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    pfam16420
    Location:9316
    ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
  2. XM_006237034.3XP_006237096.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X3

    Conserved Domains (3) summary
    cd01486
    Location:353677
    Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    TIGR01381
    Location:11688
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    pfam16420
    Location:9316
    ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
  3. XM_008763239.2XP_008761461.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

    Conserved Domains (3) summary
    cd01486
    Location:353677
    Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    TIGR01381
    Location:11688
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    pfam16420
    Location:9316
    ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    136643475..136821326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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