Mcm2 minichromosome maintenance complex component 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mcm2provided by RGD
Official Full Name: minichromosome maintenance complex component 2provided by RGD
Primary source: RGD:1305577
See related: Ensembl:ENSRNOG00000016316
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression: Biased expression in Thymus (RPKM 288.6), Spleen (RPKM 187.9) and 9 other tissues See more
Orthologs: human mouse all

Genomic context

Location:: 4q34

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (120825699..120840221, complement)
104	previous assembly	Rnor_5.0 (GCF_000001895.4)	4	NC_005103.3 (186066380..186080902, complement)

Chromosome 4 - NC_005103.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Pathways from BioSystems

Go to the top of the page Help

Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
Activation of ATR in response to replication stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
Activation of the pre-replicative complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Assembly of the pre-replicative complex, organism-specific biosystem (from REACTOME)
Assembly of the pre-replicative complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, organism-specific biosystem (from WikiPathways)
Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
DNA Replication, organism-specific biosystem (from WikiPathways)
DNA Replication, organism-specific biosystemDNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original ...
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
DNA Replication Pre-Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA replication, organism-specific biosystem (from KEGG)
DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
DNA replication, conserved biosystem (from KEGG)
DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M Checkpoints, organism-specific biosystem (from REACTOME)
G2/M Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
M/G1 Transition, organism-specific biosystem (from REACTOME)
M/G1 Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MCM complex, organism-specific biosystem (from KEGG)
MCM complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
MCM complex, conserved biosystem (from KEGG)
MCM complex, conserved biosystemStructural complex; Genetic information processing; Replication system
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
Orc1 removal from chromatin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of DNA replication, organism-specific biosystem (from REACTOME)
Regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
Removal of licensing factors from origins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
Switching of origins to a post-replicative state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Go to the top of the page Help

Markers

Mcm2 (e-PCR), detects polymorphism
- UniSTS:547455

RH142663 (e-PCR)
- UniSTS:231910

Homology

Homologs of the Mcm2 gene: The Mcm2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 258 organisms have orthologs with human gene Mcm2
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
DNA replication origin binding	IEA Inferred from Electronic Annotation more info
DNA replication origin binding	ISO Inferred from Sequence Orthology more info
enzyme binding	IEA Inferred from Electronic Annotation more info
enzyme binding	ISO Inferred from Sequence Orthology more info
helicase activity	IEA Inferred from Electronic Annotation more info
histone binding	IEA Inferred from Electronic Annotation more info
histone binding	ISO Inferred from Sequence Orthology more info
molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
DNA replication initiation	IEA Inferred from Electronic Annotation more info
DNA replication initiation	ISO Inferred from Sequence Orthology more info
DNA unwinding involved in DNA replication	IEA Inferred from Electronic Annotation more info
DNA unwinding involved in DNA replication	ISO Inferred from Sequence Orthology more info
apoptotic process	IEA Inferred from Electronic Annotation more info
apoptotic process	ISO Inferred from Sequence Orthology more info
cellular response to interleukin-4	IEA Inferred from Electronic Annotation more info
cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
cochlea development	IEA Inferred from Electronic Annotation more info
cochlea development	ISO Inferred from Sequence Orthology more info
negative regulation of DNA helicase activity	IEA Inferred from Electronic Annotation more info
nucleosome assembly	IEA Inferred from Electronic Annotation more info
nucleosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
MCM complex	IEA Inferred from Electronic Annotation more info
MCM complex	ISO Inferred from Sequence Orthology more info
chromatin	IEA Inferred from Electronic Annotation more info
chromatin	ISO Inferred from Sequence Orthology more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasm	ISO Inferred from Sequence Orthology more info
microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
nuclear origin of replication recognition complex	IEA Inferred from Electronic Annotation more info
nuclear origin of replication recognition complex	ISO Inferred from Sequence Orthology more info
NOT nucleolus	ISO Inferred from Sequence Orthology more info
nucleoplasm	IEA Inferred from Electronic Annotation more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: DNA replication licensing factor MCM2

Names: minichromosome maintenance deficient 2 mitotin

NP_001101343.2

EC 3.6.4.12

XP_006236925.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107873.2 → NP_001101343.2 DNA replication licensing factor MCM2

See identical proteins and their annotated locations for NP_001101343.2

Status: PROVISIONAL

Source sequence(s)

AC120997

UniProtKB/TrEMBL

D3ZP96

Related

ENSRNOP00000022231.5, ENSRNOT00000022231.6

Conserved Domains (4) summary

smart00350
Location:292 → 804

MCM; minichromosome maintenance proteins

pfam12619
Location:73 → 183

MCM2_N; Mini-chromosome maintenance protein 2

pfam14551
Location:199 → 311

MCM_N; MCM N-terminal domain

cl21455
Location:486 → 633

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

NC_005103.4 Reference Rnor_6.0 Primary Assembly

Range

120825699..120840221 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236863.1 → XP_006236925.1 DNA replication licensing factor MCM2 isoform X1

See identical proteins and their annotated locations for XP_006236925.1

UniProtKB/TrEMBL

D3ZP96

Conserved Domains (4) summary

smart00350
Location:292 → 804

MCM; minichromosome maintenance proteins

pfam12619
Location:73 → 183

MCM2_N; Mini-chromosome maintenance protein 2

pfam14551
Location:199 → 311

MCM_N; MCM N-terminal domain

cl21455
Location:486 → 633

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases