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Mcm2 minichromosome maintenance complex component 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312538, updated on 21-Jul-2018

Summary

Official Symbol
Mcm2provided by RGD
Official Full Name
minichromosome maintenance complex component 2provided by RGD
Primary source
RGD:1305577
See related
Ensembl:ENSRNOG00000016316
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Thymus (RPKM 288.6), Spleen (RPKM 187.9) and 9 other tissues See more
Orthologs

Genomic context

See Mcm2 in Genome Data Viewer
Location:
4q34
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120825699..120840221, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (186066380..186080902, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene podocalyxin-like 2 Neighboring gene transmembrane protein adipocyte associated 1 Neighboring gene uncharacterized LOC102554942

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

  • Homologs of the Mcm2 gene: The Mcm2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 258 organisms have orthologs with human gene Mcm2
  • Orthologs

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
histone binding IEA
Inferred from Electronic Annotation
more info
 
histone binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
DNA unwinding involved in DNA replication IEA
Inferred from Electronic Annotation
more info
 
DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
cochlea development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
MCM complex IEA
Inferred from Electronic Annotation
more info
 
MCM complex ISO
Inferred from Sequence Orthology
more info
 
chromatin IEA
Inferred from Electronic Annotation
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
nuclear origin of replication recognition complex IEA
Inferred from Electronic Annotation
more info
 
nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
 
NOT nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA replication licensing factor MCM2
Names
minichromosome maintenance deficient 2 mitotin
NP_001101343.2
XP_006236925.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107873.2NP_001101343.2  DNA replication licensing factor MCM2

    See identical proteins and their annotated locations for NP_001101343.2

    Status: PROVISIONAL

    Source sequence(s)
    AC120997
    UniProtKB/TrEMBL
    D3ZP96
    Related
    ENSRNOP00000022231.5, ENSRNOT00000022231.6
    Conserved Domains (4) summary
    smart00350
    Location:292804
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:73183
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:199311
    MCM_N; MCM N-terminal domain
    cl21455
    Location:486633
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    120825699..120840221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236863.1XP_006236925.1  DNA replication licensing factor MCM2 isoform X1

    See identical proteins and their annotated locations for XP_006236925.1

    UniProtKB/TrEMBL
    D3ZP96
    Conserved Domains (4) summary
    smart00350
    Location:292804
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:73183
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:199311
    MCM_N; MCM N-terminal domain
    cl21455
    Location:486633
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    110299649..110314061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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