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sgg shaggy [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31248, updated on 28-Aug-2019

Summary

Official Symbol
sggprovided by FlyBase
Official Full Name
shaggyprovided by FlyBase
Primary source
FLYBASE:FBgn0003371
Locus tag
Dmel_CG2621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO03040301.254; CG2621; Dm Zw3; Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3; EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta; GSK-3beta; GSK-3betaSgg; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A; Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr; GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263; l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3; SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3; zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg; zw3[sgg]; Zw3[sgg]; zw[3]

Genomic context

See sgg in Genome Data Viewer
Location:
3A8-3B1; 1-1 cM
Exon count:
26
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2633952..2679553)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2527985..2573586)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 4-kinase III alpha Neighboring gene seipin Neighboring gene brivido-3 Neighboring gene long non-coding RNA:CR45197 Neighboring gene long non-coding RNA:CR44470 Neighboring gene Helix loop helix protein 3B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
chaeta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaeta morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
chitin-based larval cuticle pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
entrainment of circadian clock IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of epithelial cell planar polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of epithelial cell planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
habituation IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development TAS
Traceable Author Statement
more info
PubMed 
imaginal disc-derived wing margin morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotor rhythm NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic growth at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
olfactory learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteolysis involved in cellular protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
pseudocleavage involved in syncytial blastoderm formation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein import into nucleus TAS
Traceable Author Statement
more info
PubMed 
regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
response to anesthetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic behavior TAS
Traceable Author Statement
more info
PubMed 
segment polarity determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic growth at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
wing and notum subfield formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
centrosome HDA PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol HDA PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
female germline ring canal IDA
Inferred from Direct Assay
more info
PubMed 
fusome IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
shaggy
Names
CG2621-PA
CG2621-PB
CG2621-PC
CG2621-PD
CG2621-PE
CG2621-PF
CG2621-PG
CG2621-PH
CG2621-PI
CG2621-PJ
CG2621-PK
CG2621-PM
CG2621-PN
CG2621-PO
CG2621-PP
CG2621-PQ
CG2621-PR
GSK-3 kinase
GSK3betagr
Shaggy/Glycogen synthase kinase 3
Shaggy/Zeste-white-3/Glycogen synthase kinase 3beta
Zeste-white3
Zw3 kinase
glycogen synthase Kinase-3
glycogen synthase kinase 3
glycogen synthase kinase 3Beta
glycogen synthase kinase-3beta
saggy
sgg-PA
sgg-PB
sgg-PC
sgg-PD
sgg-PE
sgg-PF
sgg-PG
sgg-PH
sgg-PI
sgg-PJ
sgg-PK
sgg-PM
sgg-PN
sgg-PO
sgg-PP
sgg-PQ
sgg-PR
shaggy-zeste white 3
shaggy/zeste-white 3
zest-white 3
zeste white 3
zeste white-3
zeste white3
zeste-white 3
zestewhite-3
NP_001036259.2
NP_001096870.1
NP_001162649.1
NP_001162650.1
NP_001259192.1
NP_001259193.1
NP_476714.1
NP_476715.1
NP_476716.2
NP_599105.1
NP_726822.1
NP_726823.1
NP_996334.1
NP_996335.1
NP_996336.1
NP_996337.1
NP_996338.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2633952..2679553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057366.5NP_476714.1  shaggy, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476714.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    A4V3W1
    Related
    FBpp0070450, FBtr0070467
    Conserved Domains (2) summary
    smart00220
    Location:54338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:50341
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  2. NM_206613.3NP_996336.1  shaggy, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996336.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    A4V3W1
    Related
    FBpp0089159, FBtr0070474
    Conserved Domains (2) summary
    smart00220
    Location:54338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:50341
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  3. NM_166948.4NP_726823.1  shaggy, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726823.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    A4V3W2
    Related
    FBpp0070452, FBtr0070469
    Conserved Domains (2) summary
    smart00220
    Location:54338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:50341
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  4. NM_206614.3NP_996337.1  shaggy, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996337.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    A4V3W2
    Related
    FBpp0089158, FBtr0070473
    Conserved Domains (2) summary
    smart00220
    Location:54338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:50341
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  5. NM_166947.3NP_726822.1  shaggy, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726822.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    A4V3W2
    Related
    FBpp0070451, FBtr0070468
    Conserved Domains (2) summary
    smart00220
    Location:54338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:50341
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  6. NM_057367.5NP_476715.1  shaggy, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476715.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    A4V3W2
    Related
    FBpp0070449, FBtr0070466
    Conserved Domains (2) summary
    smart00220
    Location:54338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:50341
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  7. NM_206615.2NP_996338.1  shaggy, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996338.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    A4V3W2
    Related
    FBpp0089162, FBtr0070472
    Conserved Domains (2) summary
    smart00220
    Location:54338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:50341
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  8. NM_134278.3NP_599105.1  shaggy, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599105.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    A4V3W2
    Related
    FBpp0070453, FBtr0070470
    Conserved Domains (2) summary
    smart00220
    Location:54338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:50341
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  9. NM_001169178.1NP_001162649.1  shaggy, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162649.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVY5
    Related
    FBpp0291178, FBtr0301966
    Conserved Domains (1) summary
    cd14137
    Location:1243
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  10. NM_001042794.4NP_001036259.2  shaggy, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036259.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHW6
    Related
    FBpp0304141, FBtr0331753
    Conserved Domains (2) summary
    smart00220
    Location:76360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:72363
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  11. NM_206612.3NP_996335.1  shaggy, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996335.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    B6IDN4
    Related
    FBpp0089160, FBtr0070475
    Conserved Domains (2) summary
    smart00220
    Location:36320
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:32323
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  12. NM_001169179.1NP_001162650.1  shaggy, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162650.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PUX5
    Related
    FBpp0291395, FBtr0302185
    Conserved Domains (1) summary
    cd14137
    Location:1243
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  13. NM_206611.2NP_996334.1  shaggy, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996334.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVY5
    Related
    FBpp0089161, FBtr0070476
    Conserved Domains (1) summary
    cd14137
    Location:1243
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  14. NM_001272264.1NP_001259193.1  shaggy, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259193.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGV7
    Related
    FBpp0304140, FBtr0331752
    Conserved Domains (2) summary
    smart00220
    Location:647931
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:643934
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  15. NM_001272263.1NP_001259192.1  shaggy, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259192.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGC4
    Related
    FBpp0304139, FBtr0331751
    Conserved Domains (2) summary
    smart00220
    Location:647950
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:643953
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  16. NM_057368.5NP_476716.2  shaggy, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476716.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18431
    UniProtKB/TrEMBL
    H5V852
    Related
    FBpp0070454, FBtr0070471
    Conserved Domains (2) summary
    smart00220
    Location:607891
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:603894
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  17. NM_001103400.2NP_001096870.1  shaggy, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096870.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUV9
    Related
    FBpp0111741, FBtr0112828
    Conserved Domains (2) summary
    smart00220
    Location:288535
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:284538
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
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