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Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K [ Rattus norvegicus (Norway rat) ]

Gene ID: 312381, updated on 25-Jan-2022

Summary

Official Symbol
Ppm1kprovided by RGD
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1Kprovided by RGD
Primary source
RGD:1308501
See related
Ensembl:ENSRNOG00000006893 AllianceGenome:RGD:1308501
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308501
Summary
Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 374.0), Heart (RPKM 248.5) and 9 other tissues See more
Orthologs
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Genomic context

See Ppm1k in Genome Data Viewer
Location:
4q24
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (87612198..87638993)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (88694395..88721374)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene ATP binding cassette subfamily G member 2 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein phosphatase 1K, mitochondrial
Names
protein phosphatase 1K (PP2C domain containing)
NP_001101333.1
XP_006236633.1
XP_017448105.1
XP_017448106.1
XP_017448108.1
XP_038963489.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107863.1NP_001101333.1  protein phosphatase 1K, mitochondrial

    See identical proteins and their annotated locations for NP_001101333.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474011
    UniProtKB/TrEMBL
    D4A7X5
    Related
    ENSRNOP00000009202.5, ENSRNOT00000009202.7
    Conserved Domains (1) summary
    cd00143
    Location:95346
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    87612198..87638993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236571.4XP_006236633.1  protein phosphatase 1K, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006236633.1

    UniProtKB/TrEMBL
    D4A7X5
    Conserved Domains (1) summary
    cd00143
    Location:95346
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  2. XM_017592617.2XP_017448106.1  protein phosphatase 1K, mitochondrial isoform X1

    UniProtKB/TrEMBL
    D4A7X5
    Conserved Domains (1) summary
    cd00143
    Location:95346
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  3. XM_017592616.2XP_017448105.1  protein phosphatase 1K, mitochondrial isoform X1

    UniProtKB/TrEMBL
    D4A7X5
    Conserved Domains (1) summary
    cd00143
    Location:95346
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  4. XM_017592619.2XP_017448108.1  protein phosphatase 1K, mitochondrial isoform X1

    UniProtKB/TrEMBL
    D4A7X5
    Conserved Domains (1) summary
    cd00143
    Location:95346
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  5. XM_039107561.1XP_038963489.1  protein phosphatase 1K, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd00143
    Location:16180
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
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